Deposition and Clinical Impact of Inhaled Particles in the Lung

Particles suspended in the air we breathe are deposited in the airways as a function of the properties of the particle itself (shape, size and hydration), inspiratory air flow, airway anatomy, breathing environment, and mucociliary clearance. The scientific study of the deposition of inhaled particl...

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Bibliographic Details
Published in:Archivos de bronconeumología (English ed.) 2023-06, Vol.59 (6), p.377-382
Main Authors: Clarà, Pere Casan, Jerez, Francisco Rodríguez, Ramírez, José Belda, González, Cristina Martínez
Format: Article
Language:eng ; spa
Subjects:
DMMA
Inhaled antibiotics
Inhaled drugs
Particles deposition
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Summary:Particles suspended in the air we breathe are deposited in the airways as a function of the properties of the particle itself (shape, size and hydration), inspiratory air flow, airway anatomy, breathing environment, and mucociliary clearance. The scientific study of the deposition of inhaled particles in the airways has been conducted using traditional mathematical models and imaging techniques with particle markers. In recent years, the integration of statistical and computer methods, giving rise to a new discipline called digital microfluidics, has led to significant advances. In routine clinical practice, these studies are of great use for optimizing inhaler devices in line with particular characteristics of the drug to be inhaled and the pathology of the patient.
ISSN:0300-2896
1579-2129
DOI:10.1016/j.arbres.2023.01.016