Lampbrush chromosome studies in the post‐genomic era

Extraordinary extended lampbrush chromosomes with thousands of transcription loops are favorable objects in chromosome biology. Chromosomes become lampbrushy due to unusually high rate of transcription during oogenesis. However, until recently, the information on the spectrum of transcribed sequence...

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Bibliographic Details
Published in:BioEssays 2023-05, Vol.45 (5), p.e2200250-n/a
Main Authors: Krasikova, Alla, Fishman, Veniamin, Kulikova, Tatiana
Format: Article
Language:English
Subjects:
chromatin domains
chromomere
Chromosomes
Chromosomes - genetics
Genomics
hypertranscription
Imaging techniques
Lampbrush
lampbrush chromosomes
nascent RNA
Oogenesis
transcription loop
transcription unit
Transcription, Genetic
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Summary:Extraordinary extended lampbrush chromosomes with thousands of transcription loops are favorable objects in chromosome biology. Chromosomes become lampbrushy due to unusually high rate of transcription during oogenesis. However, until recently, the information on the spectrum of transcribed sequences as well as genomic context of individual chromomeres was mainly limited to tandemly repetitive elements. Here we briefly outline novel findings and future directions in lampbrush chromosome studies in the post‐genomic era. We emphasize the fruitfulness of combining genome‐wide approaches with microscopy imaging techniques using lampbrush chromosomes as a remarkable model object. We believe that new data on the spectrum of sequences transcribed on the lateral loops of lampbrush chromosomes and their structural organization push the boundaries in the discussion of their biological role. Also see the video here: https://youtu.be/zexoHfzX9rM Extraordinary extended lampbrush chromosomes with thousands of transcription loops are favorable objects in chromosome biology. Here we briefly outline novel findings and future directions in lampbrush chromosome studies in the post‐genomic era. We emphasize the fruitfulness of combining genome‐wide approaches with microscopy imaging techniques using lampbrush chromosomes as a remarkable model object.
ISSN:0265-9247
1521-1878
DOI:10.1002/bies.202200250