Combined Histological and Endoscopic Endpoints at Post-induction Lack Additional Prognostic Value Compared with Endoscopic Improvement Alone in Ulcerative Colitis: A Post hoc Analysis of the VARSITY study

Abstract Background and Aims Evaluating histological outcomes in ulcerative colitis [UC] has become common in recent clinical trials. In this study, we explored the additional value of the combined endpoint of histo-endoscopic mucosal improvement [HEMI] compared with endoscopic improvement [EI] at p...

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Bibliographic Details
Published in:Journal of Crohn's and colitis 2023-07, Vol.17 (7), p.1114-1121
Main Authors: Wong, Emily C L, Dulai, Parambir S, Hasan, Badar, Marshall, John K, Reinisch, Walter, Narula, Neeraj
Format: Article
Language:English
Subjects:
C-Reactive Protein - metabolism
Colitis, Ulcerative - diagnosis
Colitis, Ulcerative - drug therapy
Colitis, Ulcerative - metabolism
Endoscopy
Humans
Prognosis
Remission Induction
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Summary:Abstract Background and Aims Evaluating histological outcomes in ulcerative colitis [UC] has become common in recent clinical trials. In this study, we explored the additional value of the combined endpoint of histo-endoscopic mucosal improvement [HEMI] compared with endoscopic improvement [EI] at post-induction [Week 14] and post-maintenance [1 year]. Methods This post hoc analysis included 620 UC participants with available data from the VARSITY trial. Participants achieving post-induction and post-maintenance HEMI [Mayo endoscopic subscore ≤1 and Geboes score 
ISSN:1873-9946
1876-4479
DOI:10.1093/ecco-jcc/jjad033