Social navigation modulates the anterior and posterior hippocampal circuits in the resting brain

Social navigation is a dynamic and complex process that requires the collaboration of multiple brain regions. However, the neural networks for navigation in a social space remain largely unknown. This study aimed to investigate the role of hippocampal circuit in social navigation from a resting-stat...

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Bibliographic Details
Published in:Brain Structure and Function 2023-05, Vol.228 (3-4), p.799-813
Main Authors: Wu, Xiaoyan, Zhang, Lu, Liu, Bingyi, Liao, Jiajun, Qiu, Yidan, Huang, Ruiwang
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Brain
Brain Mapping
Cell Biology
Cerebellum
Cognition
Cognition & reasoning
Cognitive models
Cortex (cingulate)
Cortex (parietal)
Frontal gyrus
Functional magnetic resonance imaging
Hippocampus
Hippocampus - diagnostic imaging
Humans
Laboratories
Magnetic Resonance Imaging
Memory
Neural networks
Neurology
Neurosciences
Neurosis
Original Article
Parietal Lobe
Personality
Personality traits
Seeds
Social interactions
Social skills
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Summary:Social navigation is a dynamic and complex process that requires the collaboration of multiple brain regions. However, the neural networks for navigation in a social space remain largely unknown. This study aimed to investigate the role of hippocampal circuit in social navigation from a resting-state fMRI data. Here, resting-state fMRI data were acquired before and after participants performed a social navigation task. By taking the anterior and posterior hippocampus (HPC) as the seeds, we calculated their connectivity with the whole brain using the seed-based static functional connectivity (sFC) and dynamic FC (dFC) approaches. We found that the sFC and dFC between the anterior HPC and supramarginal gyrus, sFC or dFC between posterior HPC and middle cingulate cortex, inferior parietal gyrus, angular gyrus, posterior cerebellum, medial superior frontal gyrus were increased after the social navigation task. These alterations were related to social cognition of tracking location in the social navigation. Moreover, participants who had more social support or less neuroticism showed a greater increase in hippocampal connectivity. These findings may highlight a more important role of the posterior hippocampal circuit in the social navigation, which is crucial for social cognition.
ISSN:1863-2661
1863-2653
1863-2661
0340-2061
DOI:10.1007/s00429-023-02622-1