Association of peak C-reactive protein with long-term clinical outcomes in patients with ST-segment elevation myocardial infarction

Peak C-reactive protein (CRP) levels following ST-segment elevation myocardial infarction (STEMI) are associated with left ventricular thrombus formation or cardiac rupture. However, the impact of peak CRP on long-term outcomes in patients with STEMI is not completely understood. The purpose of this...

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Bibliographic Details
Published in:Heart and vessels 2023-06, Vol.38 (6), p.764-772
Main Authors: Hori, Yoichi, Sakakura, Kenichi, Jinnouchi, Hiroyuki, Taniguchi, Yousuke, Tsukui, Takunori, Watanabe, Yusuke, Yamamoto, Kei, Seguchi, Masaru, Wada, Hiroshi, Fujita, Hideo
Format: Article
Language:English
Subjects:
Biomedical Engineering and Bioengineering
C-reactive protein
C-Reactive Protein - metabolism
Cardiac Surgery
Cardiology
Clinical outcomes
Death
Hazard assessment
Heart
Heart attacks
Humans
Medicine
Medicine & Public Health
Mortality
Multivariate Analysis
Myocardial infarction
Original Article
Percutaneous Coronary Intervention - methods
Proportional Hazards Models
Proteins
Retrospective Studies
Segments
ST Elevation Myocardial Infarction - diagnosis
Thrombosis
Vascular Surgery
Ventricle
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Summary:Peak C-reactive protein (CRP) levels following ST-segment elevation myocardial infarction (STEMI) are associated with left ventricular thrombus formation or cardiac rupture. However, the impact of peak CRP on long-term outcomes in patients with STEMI is not completely understood. The purpose of this retrospective study was to compare the long-term all-cause death after STEMI between patients with and without high peak CRP levels. We included 594 patients with STEMI, and divided them into the high CRP group ( n  = 119) and the low-moderate CRP group ( n  = 475) according to the quintile of peak CRP levels. The primary endpoint was all-cause death after the discharge of the index admission. The mean peak CRP level was 19.66 ± 5.14 mg/dL in the high CRP group, whereas that was 6.43 ± 3.86 mg/dL in the low-moderate CRP group ( p  
ISSN:0910-8327
1615-2573
DOI:10.1007/s00380-023-02250-z