Celastrus paniculatus oil ameliorates NF-KB mediated neuroinflammation and synaptic plasticity in the scopolamine-induced cognitive impairment rat model

Background and Aim: Traditionally, Celastrus paniculatus Willd. (CP) oil has been utilized as a tranquilizer and memory enhancer. The present study investigated the neuropharmacological activity and efficacy of CP oil in ameliorating scopolamine-induced cognitive impairment in rats. Experimental pro...

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Bibliographic Details
Published in:Metabolic brain disease 2023-04, Vol.38 (4), p.1405-1419
Main Authors: Faldu, Khushboo Govind, Patel, Snehal Sanjay, Shah, Jigna Samir
Format: Article
Language:English
Subjects:
Acetylcholinesterase
Acetylcholinesterase - metabolism
Amnesia
Animal behavior
Animals
Avoidance
Avoidance behavior
Biochemistry
Biomarkers
Biomedical and Life Sciences
Biomedicine
Catalase
Celastrus - metabolism
Celastrus paniculatus
Cholinergics
Cognitive ability
Cognitive Dysfunction - chemically induced
Cognitive Dysfunction - drug therapy
Donepezil
Dopamine
Glutathione
Growth factors
Immunohistochemistry
Impairment
Inflammation
Interleukin 6
Interleukin-6 - metabolism
Latency
Maze Learning
Metabolic Diseases
Nerve growth factor
Nerve Growth Factor - metabolism
Neuroinflammatory Diseases
Neurology
Neuronal Plasticity
Neurosciences
NF-kappa B - metabolism
NF-κB protein
Noradrenaline
Norepinephrine
Oil
Oncology
Original Article
Oxidative Stress
Plant Extracts - pharmacology
Plasticity
Rats
Scopolamine
Serotonin
Stress concentration
Superoxide dismutase
Synaptic plasticity
Synaptophysin
Synaptophysin - metabolism
Tumor Necrosis Factor-alpha - metabolism
Tumor necrosis factor-α
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Summary:Background and Aim: Traditionally, Celastrus paniculatus Willd. (CP) oil has been utilized as a tranquilizer and memory enhancer. The present study investigated the neuropharmacological activity and efficacy of CP oil in ameliorating scopolamine-induced cognitive impairment in rats. Experimental procedure: Cognitive deficiency was induced in rats by administration of scopolamine (2 mg/kg intraperitoneal injection) for a period of 15 days. Donepezil served as a reference drug and CP oil was tested as both preventive and curative treatments. Animals’ behaviour was assessed through the Morris water maze (MWM), novel object preference (NOR), and conditioned avoidance (CA) tests. Oxidative stress parameters, bioamine concentration (dopamine, noradrenaline, and 5-hydroxytryptamine), nerve growth factor (NGF), interleukin-6 (IL-6), nuclear factor kappa B (NF-кB), and tumor necrosis factor-alpha (TNFα) were estimated. Synaptophysin immunohistochemistry was performed. Results: Our results showed that CP oil ameliorated behavioural deficits. It reduced latency to find a hidden platform in MWM. Reduced novel object exploration time and discrimination index (p 
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-023-01186-7