Determination of the Effects of Bee Venom on Triple Negative Breast Cancer Cells in Vitro

Honeybees provide multiple products such as bee venom (BV) which are used for various nutritional and medicinal purposes. BV has received great attention due to its wide range of bioactive components with potential anti‐cancer effects on different cancers. Triple negative breast cancer (TNBC) is def...

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Bibliographic Details
Published in:Chemistry & biodiversity 2023-03, Vol.20 (3), p.e202201263-n/a
Main Authors: Sevin, Sedat, Deveci Ozkan, Asuman, Tutun, Hidayet, Kivrak, Ibrahim, Turna, Ozge, Guney Eskiler, Gamze
Format: Article
Language:English
Subjects:
Animals
Annexin V
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Apoptosis
bee venom
Bee Venoms - pharmacology
Bee Venoms - therapeutic use
Bees
Bioactive compounds
Biological activity
Breast cancer
Cell cycle
Cell death
Cell Line, Tumor
Cytotoxicity
honey bee
Humans
Pharmacology
Therapeutic targets
triple negative breast cancer (TNBC)
Triple Negative Breast Neoplasms - drug therapy
Venom
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Summary:Honeybees provide multiple products such as bee venom (BV) which are used for various nutritional and medicinal purposes. BV has received great attention due to its wide range of bioactive components with potential anti‐cancer effects on different cancers. Triple negative breast cancer (TNBC) is defined as an aggressive type of breast cancer and new therapeutic targets are required for its treatment. In the current literature information is varied about the composition and quantity of BV bioactive compounds as well as the origin of BV and its significance. In this context, the cytotoxic and apoptotic effects of BV with a higher rate of mellitin from Apis mellifera anatoliaca (Muğla ecotype) on MDA‐MB‐231 cells was evaluated, in vitro. The cytotoxic, apoptotic and morphological effects of BV were determined by WST‐1, Annexin V, cell cycle analysis and Acridine Orange staining. The results showed that BV caused apoptotic cell death in TNBC cells at a lower dose (0.47 μg/mL, p
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202201263