The BDNF-TrkB signaling pathway is partially involved in the neuroprotective effects of hydrogen sulfide in Parkinson's disease

Recent studies have demonstrated that hydrogen sulfide (H2S) has a neuroprotective effect in neurodegenerative diseases. It is possible that this effect is supported by brain-derived neurotrophic factor (BDNF). Our aim is to examine the effects of H2S on neural damage in Parkinson's disease (PD...

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Published in:European journal of pharmacology 2023-04, Vol.944, p.175595-175595, Article 175595
Main Authors: Hacioglu, Gulay, Cirrik, Selma, Tezcan Yavuz, Berna, Tomruk, Canberk, Keskin, Arif, Uzunoglu, Emel, Takir, Selcuk
Format: Article
Language:English
Subjects:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology
Animals
Apoptosis
BDNF
Brain-Derived Neurotrophic Factor - metabolism
Disease Models, Animal
Hydrogen sulfide
Hydrogen Sulfide - metabolism
K252a
Male
Mice
Mice, Inbred C57BL
Neuroprotective Agents - pharmacology
Parkinson Disease - metabolism
Parkinson's disease
Receptor, trkB - metabolism
Signal Transduction
TrkB receptor
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Summary:Recent studies have demonstrated that hydrogen sulfide (H2S) has a neuroprotective effect in neurodegenerative diseases. It is possible that this effect is supported by brain-derived neurotrophic factor (BDNF). Our aim is to examine the effects of H2S on neural damage in Parkinson's disease (PD) and to reveal the role of the BDNF-TrkB pathway in its possible effect. PD model was created with 1-methyl-phenyl-1,2,3,6-tetrahydropyridine (MPTP). C57BL/6 breed male mice were randomly divided into six groups: control, K252a, MPTP, MPTP + K252a, MPTP + NaHS, and MPTP + NaHS + K252a. TrkB receptor antagonist K252a and sodium hydrosulfide (NaHS) as a H2S donor were administered intraperitoneally. An increase was observed in the motor behavior tests in MPTP group, but NaHS treatment shortened the time spent on the balance beam and pole tests. It was also noticed that the BDNF-pathway played a role in the shortening of this period. Mice that received NaHS were found to have less MPTP-induced cellular damage. A positive effect of BDNF was also detected in the protection of these neurons. BDNF levels in the SN were significantly increased in MPTP group, compared to control group. Tissue CBS levels decreased in the groups that received K252a, compared to MPTP group. The findings of the present study display that the BDNF-TrkB pathway partially plays a role in the protective effect of H2S in the experimental mouse model of PD. This effect is probably due to changes in intracellular signaling pathways, rather than TrkB receptor expression.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2023.175595