Systemic Immune-Inflammation Index Predicts Acute Symptomatic Hydrocephalus After Spontaneous Nonaneurysmal Subarachnoid Hemorrhage

The authors sought to investigate the association between white blood cell counts and acute hydrocephalus in spontaneous nonaneurysmal subarachnoid hemorrhage (nSAH). We conducted a retrospective analysis of 105 consecutive patients with spontaneous nSAH. Univariate and multivariable logistic regres...

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Bibliographic Details
Published in:World neurosurgery 2023-05, Vol.173, p.e378-e390
Main Authors: Cuoco, Joshua A., Guilliams, Evin L., Adhikari, Srijan, Rogers, Cara M., Marvin, Eric A., Patel, Biraj M., Entwistle, John J.
Format: Article
Language:English
Subjects:
Humans
Hydrocephalus
Hydrocephalus - complications
Inflammation - complications
Lymphocytes
Nonperimesencephalic
Perimesencephalic
Prognosis
Retrospective Studies
Subarachnoid hemorrhage
Subarachnoid Hemorrhage - complications
Systemic immune-inflammation index
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Summary:The authors sought to investigate the association between white blood cell counts and acute hydrocephalus in spontaneous nonaneurysmal subarachnoid hemorrhage (nSAH). We conducted a retrospective analysis of 105 consecutive patients with spontaneous nSAH. Univariate and multivariable logistic regression analyses were performed to investigate factors associated with hydrocephalus. Receiver operating characteristic curve analysis determined the optimal cutoff to differentiate between patients with and without hydrocephalus. The admission characteristics of hydrocephalic patients with aneurysmal and nSAH were compared. A total of 70 patients met inclusion criteria, of which 21 (30%) presented with hydrocephalus. In univariate logistic regression, leukocytes, neutrophils, lymphocytes, neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, neutrophil-monocyte-to-lymphocyte ratio, and the systemic immune-inflammation (SII) index ([neutrophils × platelets/lymphocytes]/1000) were associated with hydrocephalus. After adjustments, the SII index independently predicted acute hydrocephalus with the highest odds among laboratory values (odds ratio 2.184, P = 0.006). Receiver operating characteristic curve analysis revealed the SII index differentiated between patients with and without hydrocephalus (area under the curve = 0.799, 95% CI: 0.688–0.909, P 
ISSN:1878-8750
1878-8769
1878-8769
DOI:10.1016/j.wneu.2023.02.060