Physical capacity increase in patients with heart failure is associated with improvement in muscle sympathetic nerve activity

Exercise training improves physical capacity in patients with heart failure with reduced ejection fraction (HFrEF), but the mechanisms involved in this response is not fully understood. The aim of this study was to determine if physical capacity increase in patients HFrEF is associated with muscle s...

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Bibliographic Details
Published in:International journal of cardiology 2023-05, Vol.378, p.48-54
Main Authors: Goes-Santos, Beatriz R., Rondon, Eduardo, Fonseca, Guilherme W.P., Sales, Allan R.K., Santos, Marcelo R., Antunes-Correa, Ligia M., Ueno-Pardi, Linda M., Oliveira, Patrícia, Trevizan, Patricia F., Mello Franco, Fábio G., Fraga, Raffael, Alves, Maria Janieire N.N., Rondon, Maria Urbana P.B., Hajjar, Ludhmila A., Filho, Roberto Kalil, Negrão, Carlos E.
Format: Article
Language:English
Subjects:
Blood Pressure
Exercise
Exercise Therapy
Exercise training
Heart failure
Heart Failure - diagnosis
Heart Failure - therapy
Humans
Muscle sympathetic nerve activity
Muscle, Skeletal
Peak oxygen consumption
Stroke Volume
Sympathetic Nervous System
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Summary:Exercise training improves physical capacity in patients with heart failure with reduced ejection fraction (HFrEF), but the mechanisms involved in this response is not fully understood. The aim of this study was to determine if physical capacity increase in patients HFrEF is associated with muscle sympathetic nerve activity (MSNA) reduction and muscle blood flow (MBF) increase. The study included 124 patients from a 17-year database, divided according to exercise training status: 1) exercise-trained (ET, n = 83) and 2) untrained (UNT, n = 41). MSNA and MBF were obtained using microneurography and venous occlusion plethysmography, respectively. Physical capacity was evaluated by cardiopulmonary exercise test. Moderate aerobic exercise was performed 3 times/wk. for 4 months. Exercise training increased peak oxygen consumption (V̇O2, 16.1 ± 0.4 vs 18.9 ± 0.5 mL·kg−1·min−1, P 
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2023.02.018