Comparison of pharmacokinetics of two tylvalosin oral formulations in broiler chickens

The objective of the study was to compare the relative bioavailability and pharmacokinetics of two commercially available oral formulations of tylvalosin prepared for use in broiler chickens (ProviLosinR and AviLosinR). A total of 36 healthy, broiler chickens were administered a single oral dose (25...

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Bibliographic Details
Published in:Journal of veterinary pharmacology and therapeutics 2023-05, Vol.46 (3), p.165-169
Main Authors: Abu‐Basha, Ehab A., Bani Ismail, Zuhair, Idkaidek, Nasir M., Hamzeh, Eyad
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Area Under Curve
Biological Availability
broiler chickens
Chickens
macrolide antibiotics
pharmacokinetics
Tylosin - pharmacokinetics
tylvalosin
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Summary:The objective of the study was to compare the relative bioavailability and pharmacokinetics of two commercially available oral formulations of tylvalosin prepared for use in broiler chickens (ProviLosinR and AviLosinR). A total of 36 healthy, broiler chickens were administered a single oral dose (25 mg/kg b.w.) of each formulation in a parallel randomized design. The relative bioavailability of ProviLosinR was 108% compared to AviLosinR. There were no significant differences between ProviLosinR and AviLosinR tylvalosin formulations in the average means of the area under the plasma concentration–time curve, maximum plasma concentrations and time to maximum plasma concentrations. In conclusion, tylvalosin was rapidly absorbed and relatively slowly eliminated after oral administration of a single dose for both formulations. ProviLosinR and AviLosinR can be used interchangeably as therapeutic agents in broiler chickens.
ISSN:0140-7783
1365-2885
DOI:10.1111/jvp.13116