Photophysical, photobiological, and biomolecule-binding properties of new tri-cationic meso-tri(2-thienyl)corroles with Pt(II) and Pd(II) polypyridyl derivatives

We report the synthesis and characterization of new tri-cationic corrole derivatives, containing Pt(II) or Pd(II) complexes attached at the peripheral position of thienyl moieties. Corrole derivatives were characterized through microanalysis, electrochemical, spectrometry and spectroscopy analysis....

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Published in:Journal of inorganic biochemistry 2023-05, Vol.242, p.112149-112149, Article 112149
Main Authors: Rodrigues, Bruna M., Victória, Henrique F.V., Leite, Guilherme, Krambrock, Klaus, Chaves, Otávio A., de Oliveira, Diego F., Garcia, Rafael de Q., De Boni, Leonardo, Costa, Luiz A.S., Iglesias, Bernardo A.
Format: Article
Language:English
Subjects:
Corroles
Humans
Molecular Docking Simulation
Palladium(II) corroles
Photobiology
Platinum(II) corroles
Porphyrins - chemistry
Spectrometry, Fluorescence
Thienyl-corroles
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Summary:We report the synthesis and characterization of new tri-cationic corrole derivatives, containing Pt(II) or Pd(II) complexes attached at the peripheral position of thienyl moieties. Corrole derivatives were characterized through microanalysis, electrochemical, spectrometry and spectroscopy analysis. Singlet and triplet excited-states are investigated by photophysical/theoretical calculation methods and photobiological parameters were also evaluated spectroscopic techniques (UV–Vis and EPR). Also, the binding capacity of each corrole derivative with nucleic acids (DNA) and human serum albumin (HSA) was determined by UV–Vis, steady-state, and time-resolved fluorescence spectroscopy, combined with molecular docking analysis. Moreover, the new corroles containing peripheral complexes improve their interactions with biomacromolecules, generate reactive oxygen species under light source irradiation studied and has potential for application in photodynamic therapeutic processes. Synthesis, characterization, photophysical/photobiological and biomolecule interaction of novel tri-cationic corroles. [Display omitted] •Synthesis of novel meso-tri(2-thienyl)corroles with peripheral Pt(II) or Pd(II)-polypyridyl complexes.•Photophysical and photobiological properties of tri-cationic thienyl corrole derivatives.•Peripheral Pt(II)-or Pd(II)-corroles as good reactive oxygen species (ROS) generators.•Cationic corroles in DNA and human serum albumin (HSA) bio-interactions.
ISSN:0162-0134
1873-3344
DOI:10.1016/j.jinorgbio.2023.112149