RNA-binding proteins in vascular inflammation and atherosclerosis

Atherosclerotic cardiovascular disease (ASCVD) remains the major cause of premature death and disability worldwide, even when patients with an established manifestation of atherosclerotic heart disease are optimally treated according to the clinical guidelines. Apart from the epigenetic control of t...

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Bibliographic Details
Published in:Atherosclerosis 2023-06, Vol.374, p.55-73
Main Authors: Sachse, Marco, Tual-Chalot, Simon, Ciliberti, Giorgia, Amponsah-Offeh, Michael, Stamatelopoulos, Kimon, Gatsiou, Aikaterini, Stellos, Konstantinos
Format: Article
Language:English
Subjects:
Atherosclerosis
Atherosclerosis - genetics
Atherosclerosis - metabolism
Endothelial cell
Humans
Immune cell
Inflammation
Inflammation - genetics
RNA-binding proteins
RNA-Binding Proteins - genetics
RNA-Binding Proteins - metabolism
Smooth muscle cell
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Summary:Atherosclerotic cardiovascular disease (ASCVD) remains the major cause of premature death and disability worldwide, even when patients with an established manifestation of atherosclerotic heart disease are optimally treated according to the clinical guidelines. Apart from the epigenetic control of transcription of the genetic information to messenger RNAs (mRNAs), gene expression is tightly controlled at the post-transcriptional level before the initiation of translation. Although mRNAs are traditionally perceived as the messenger molecules that bring genetic information from the nuclear DNA to the cytoplasmic ribosomes for protein synthesis, emerging evidence suggests that processes controlling RNA metabolism, driven by RNA-binding proteins (RBPs), affect cellular function in health and disease. Over the recent years, vascular endothelial cell, smooth muscle cell and immune cell RBPs have emerged as key co- or post-transcriptional regulators of several genes related to vascular inflammation and atherosclerosis. In this review, we provide an overview of cell-specific function of RNA-binding proteins involved in all stages of ASCVD and how this knowledge may be used for the development of novel precision medicine therapeutics. [Display omitted] •RNA-binding protein (RBP) function demonstrates a high degree of cell-specific effect in atherosclerosis.•RBPs are critical effectors of gene expression and emerge as key players of vascular inflammation and atherosclerosis.•Modulation of one RBP may alter the expression of several disease-related genes affecting a plethora of cellular functions.•Future studies are needed to report the organ- and cell-specific biological and clinical relevance of RBPs in atherosclerosis.
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2023.01.008