Right Ventricular Dysfunction in Patients With Concomitant Tricuspid Regurgitation Undergoing Transcatheter Aortic Valve Implantation

Background: This study investigated the impact and predictive factors of concomitant significant tricuspid regurgitation (TR) and evaluated the roles of right ventricle (RV) function and the etiology of TR in the clinical outcomes of patients with severe aortic stenosis undergoing transcatheter aort...

Full description

Saved in:
Bibliographic Details
Published in:Circulation Journal 2024/03/25, Vol.88(4), pp.451-459
Main Authors: Jongh, Marjolein C. de, Tsuruta, Hikaru, Hayashida, Kentaro, Hase, Hiromu, Yoshijima, Nobuhiro, Saito, Tetsuya, Myojin, Sosuke, Kobari, Yusuke, Ryuzaki, Toshinobu, Imaeda, Shohei, Shirakawa, Kohsuke, Okada, Marina, Endo, Jin, Shinada, Keitaro, Itabashi, Yuji, Inohara, Taku, Kohsaka, Shun, Kato, Jungo, Takahashi, Tatsuo, Yamazaki, Masataka, Shimizu, Hideyuki, Fukuda, Keiichi
Format: Article
Language:English
Subjects:
Aortic stenosis
Aortic Valve - surgery
Aortic Valve Stenosis - complications
Aortic Valve Stenosis - surgery
Humans
Retrospective Studies
Right ventricular dysfunction
Transcatheter aortic valve implantation
Transcatheter Aortic Valve Replacement - adverse effects
Treatment Outcome
Tricuspid regurgitation
Tricuspid Valve Insufficiency - surgery
Ventricular Dysfunction, Right - etiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: This study investigated the impact and predictive factors of concomitant significant tricuspid regurgitation (TR) and evaluated the roles of right ventricle (RV) function and the etiology of TR in the clinical outcomes of patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI).Methods and Results: We assessed grading of TR severity, TR etiology, and RV function in pre- and post-TAVI transthoracic echocardiograms for 678 patients at Keio University School of Medicine. TR etiology was divided into 3 groups: primary TR, ventricular functional TR (FTR), and atrial FTR. The primary outcomes were all-cause and cardiovascular death. At baseline, moderate or greater TR was found in 55 (8%) patients and, after adjustment for comorbidities, was associated with increased all-cause death (hazard ratio [HR] 2.11; 95% confidence interval [CI] 1.19−3.77; P=0.011) and cardiovascular death (HR 2.29; 95% CI 1.06−4.99; P=0.036). RV dysfunction (RVD) also remained an independent predictor of cardiovascular death (HR 2.06; 95% CI 1.03−4.14; P=0.042). Among the TR etiology groups, patients with ventricular FTR had the lowest survival rate (P
ISSN:1346-9843
1347-4820
1347-4820
DOI:10.1253/circj.CJ-22-0262