A Nonswelling Hydrogel with Regenerable High Wet Tissue Adhesion for Bioelectronics

Reducing the swelling of tissue‐adhesive hydrogels is crucial for maintaining stable tissue adhesion and inhibiting tissue inflammation. However, reported strategies for reducing swelling always result in a simultaneous decrease in the tissue adhesive strength of the hydrogel. Furthermore, once the...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2023-05, Vol.35 (18), p.e2212302-n/a
Main Authors: Tian, Gongwei, Yang, Dan, Liang, Cuiyuan, Liu, Yan, Chen, Jianhui, Zhao, Qinyi, Tang, Shuanglong, Huang, Jianping, Xu, Ping, Liu, Zhiyuan, Qi, Dianpeng
Format: Article
Language:English
Subjects:
Acrylic acid
Adhesion
Adhesive strength
Adhesives
bifunctional bioelectronics
biophysical signals
Bonding strength
Chemical bonds
Chitosan
Chitosan - chemistry
Copolymerization
Covalent bonds
Crosslinking
Gelatin
Gelatin - chemistry
Hydrogels
Hydrogels - chemistry
Materials science
Muscles
Muscular fatigue
nonswelling hydrogel adhesives
on‐demand detachment
Polyvinyl acetal resins
Polyvinyl butyral
Prostheses
regenerable tissue adhesion
Sensor arrays
Substrates
Swelling
Tissue Adhesives - chemistry
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Summary:Reducing the swelling of tissue‐adhesive hydrogels is crucial for maintaining stable tissue adhesion and inhibiting tissue inflammation. However, reported strategies for reducing swelling always result in a simultaneous decrease in the tissue adhesive strength of the hydrogel. Furthermore, once the covalent bonds break in the currently reported hydrogels, they cannot be rebuilt, and the hydrogel loses its tissue adhesive ability. In this work, a nonswelling hydrogel (named as “PAACP”) possessing regenerable high tissue adhesion is synthesized by copolymerizing and crosslinking poly(vinyl butyral) with acrylic acid, gelatin, and chitosan‐grafted N‐acetyl‐l‐cysteine. The tissue adhesive strength of the obtained PAACP reaches 211.4 kPa, which is approximately ten times higher than that of the reported nonswelling hydrogels, and the hydrogel can be reused for multiple cycles. The as‐prepared hydrogel shows great potential in soft bioelectronics, as muscle fatigue is successfully monitored via the electrode array and strain sensor integrated on PAACP substrates. The success of these bioelectronics offers potential applicability in the long‐term diagnosis of muscle‐related health conditions and prosthetic manipulations. Nonswelling hydrogels with regenerable high wet tissue adhesion are fabricated. Subsequently, neural microelectrode arrays and rapid‐response strain sensors are integrated into the hydrogel to fabricate bifunctional tissue‐interface bioelectronics. Additionally, these bioelectronics possess excellent electrical properties. Electrocardiogram (ECG), electromyography (EMG), and tissue movement information are accurately recorded by the bioelectronics, and tissue fatigue is successfully monitored.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.202212302