Diorygmones A-B, two new guaiane-sesquiterpenes from the cultured lichen mycobiont of Diorygma sp

Diorygma sp. is a native crustose-lichen in Vietnam. A mycobiont of this lichen was isolated, then cultivated. The present study described the isolation and structural elucidation of two new guaiane-type sesquiterpenes, namely diorygmones A-B. Their absolute chemical structures were elucidated by ex...

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Bibliographic Details
Published in:Natural product research 2024-07, Vol.38 (13), p.2282-2287
Main Authors: Nguyen, Huu-Hung, Aree, Thammarat, Nguyen, Huy Truong, Tran, Thi-Minh-Dinh, Nguyen, Thi-Phuong, Vo, Thi-Phi Giao, Nguyen, Ngoc-Hong, Duong, Thuc-Huy
Format: Article
Language:English
Subjects:
Circular dichroism
Cultured lichen mycobiont
Cytotoxicity
Dichroism
Diorygma pruinosum
diorygmone
guaiane
Lichens
Mass spectroscopy
NMR
Nuclear magnetic resonance
Sesquiterpenes
Two dimensional analysis
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Summary:Diorygma sp. is a native crustose-lichen in Vietnam. A mycobiont of this lichen was isolated, then cultivated. The present study described the isolation and structural elucidation of two new guaiane-type sesquiterpenes, namely diorygmones A-B. Their absolute chemical structures were elucidated by extensive 1D and 2D NMR analysis, high-resolution mass spectroscopy, electronic circular dichroism (ECD), and comparisons with the literatures. Compounds 1 and 2 were evaluated for cytotoxic activity against HepG2 cell line.
ISSN:1478-6419
1478-6427
1478-6427
DOI:10.1080/14786419.2023.2172007