Cervical Lymph Node Metastasis From Recurrent Glioblastoma Detected by MRI and 2-[18F]FDG PET/CT

A 53-year-old man diagnosed with recurrent glioblastoma after multimodal treatment on a follow-up brain MRI. Because of a palpable mass in the neck, the patient underwent a whole-body 2-[18F]FDG PET/CT, which revealed hypermetabolic laterocervical confluent lymphadenopathies. A nodal cervical biopsy...

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Bibliographic Details
Published in:Clinical nuclear medicine 2023-03, Vol.48 (3), p.e118-e120
Main Authors: Suárez-Piñera, Marina, Pudis, Michal, Vilariño, Noelia, Baixeras, Nuria, Torró, Carlos Majós
Format: Article
Language:English
Subjects:
Female
Fluorodeoxyglucose F18
Glioblastoma - diagnostic imaging
Glioblastoma - pathology
Humans
Lymph Nodes - pathology
Lymphatic Metastasis - diagnostic imaging
Lymphatic Metastasis - pathology
Magnetic Resonance Imaging
Male
Middle Aged
Positron Emission Tomography Computed Tomography
Positron-Emission Tomography
Radiopharmaceuticals
Sensitivity and Specificity
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Summary:A 53-year-old man diagnosed with recurrent glioblastoma after multimodal treatment on a follow-up brain MRI. Because of a palpable mass in the neck, the patient underwent a whole-body 2-[18F]FDG PET/CT, which revealed hypermetabolic laterocervical confluent lymphadenopathies. A nodal cervical biopsy indicated distant metastases from glioblastoma. Recent studies have confirmed dural meningeal lymphatics, as part of the glymphatic system, which provide clearance of interstitial solutes from the brain parenchyma into cervical lymphatics. Nodal cervical metastases from glioblastoma, using this pathway, are extremely rare and have been almost unthinkable some years ago.
ISSN:0363-9762
1536-0229
DOI:10.1097/RLU.0000000000004546