Severe Mpox Infections in People With Uncontrolled Human Immunodeficiency Virus

Abstract In the current mpox outbreak, infections are usually self-limited. We describe 3 patients with uncontrolled HIV and mpox infections lasting months, causing debilitating lesions, complications, and death, despite initiating anti-mpox and antiretroviral therapy. Delayed treatment of mpox with...

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Bibliographic Details
Published in:Clinical infectious diseases 2023-05, Vol.76 (10), p.1843-1846
Main Authors: Govind, Anusha, Lazarte, Susana M, Kitchell, Ellen, Chow, Jeremy Y, Estelle, Carolee D, Fixsen, Emma, Helm, Caitlin, Jain, Mamta K, Mehta, Roma, Perl, Trish M, Sutaria, Jaini M, Thomas, Cristina, Dominguez, Arturo R, Utay, Netanya S
Format: Article
Language:English
Subjects:
Antiviral Agents - therapeutic use
Disease Outbreaks
HIV
HIV Infections - complications
HIV Infections - drug therapy
Humans
Mpox (monkeypox) - complications
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Summary:Abstract In the current mpox outbreak, infections are usually self-limited. We describe 3 patients with uncontrolled HIV and mpox infections lasting months, causing debilitating lesions, complications, and death, despite initiating anti-mpox and antiretroviral therapy. Delayed treatment of mpox with antiviral agents may contribute to poor outcomes in severely immunocompromised patients.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciad052