Transfusions with laboratory-grown red blood cells: a new development in science

•Recovery and Survival of Stem Cell Originated Red Cells (RESTORE) trial is an initiative by the “NHS Blood and Transplant, University of Bristol, National Institute for Health and Care Research Cambridge Clinical Facility,” in association with several other partner organizations.•To our knowledge,...

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Bibliographic Details
Published in:Experimental hematology 2023-03, Vol.119-120, p.1-2
Main Authors: Kutikuppala, Lakshmi Venkata Simhachalam, Ponnaganti, Sai Venkata Kalyani, Kale, Sampreeti Sri Sai, Kode, Rohith, Kuchana, Sai Kiran
Format: Article
Language:English
Subjects:
Blood Transfusion
Erythrocyte Transfusion
Erythrocytes
Humans
Tissue Donors
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Summary:•Recovery and Survival of Stem Cell Originated Red Cells (RESTORE) trial is an initiative by the “NHS Blood and Transplant, University of Bristol, National Institute for Health and Care Research Cambridge Clinical Facility,” in association with several other partner organizations.•To our knowledge, this procedure was the first to deliver laboratory-grown cells to another individual through a blood transfusion, which is an advancement in laboratory innovations.•This research offers hope to those patients who have been facing difficulty in transfusions because of the development of antibodies against donor blood cells. It is inevitable to anticipate the development of laboratory abilities and their involvement in clinical research in a fast-paced world. The RESTORE study is one such incident that has drawn the interest of various specialists. Red blood cells (RBCs) that have been generated in a laboratory have been transfused into a volunteer in this trial. To our knowledge, this procedure was the first to deliver laboratory-grown cells to another individual through a blood transfusion, which is an advancement in laboratory innovations. The purpose of the research was to determine how long a mini-transfusion of up to two teaspoons or 10 mL of laboratory-grown RBCs will persist in the body in comparison with an equivalent quantity of regular cells from the same donor. Assuming the process can be scaled up to a standard transfusion, this approach is advantageous because it can address the shortage of donors for those with rare blood types. Laboratory-grown blood cells are anticipated to last longer and perform better, which is another benefit to be noticed. This study represents a tremendous advancement in scientific innovation and teamwork while providing high-quality care to those who need it the most, although additional trials are required before clinical usage.
ISSN:0301-472X
1873-2399
DOI:10.1016/j.exphem.2023.01.004