Risk Factors Related to Early Biliary Complications After Liver Transplantation: a Single-Center Analysis

•The risk factors of early biliary complications after liver transplantation were studied.•The time to bile outflow after liver transplantation was evaluated first.•Warm ischemia time and operative time were independent risk factors. The aim of this study was to evaluate the risk factors of early bi...

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Bibliographic Details
Published in:Transplantation proceedings 2023-01, Vol.55 (1), p.164-169
Main Authors: Suo, Lida, Liang, Xiangnan, Zhang, Weibin, Ma, Taiheng, Gao, Zhenming
Format: Article
Language:English
Subjects:
Adult
Biliary Tract Diseases - etiology
Cholangiopancreatography, Endoscopic Retrograde - adverse effects
Cholestasis - etiology
Constriction, Pathologic - etiology
Humans
Liver Transplantation - methods
Postoperative Complications - etiology
Retrospective Studies
Risk Factors
Treatment Outcome
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Summary:•The risk factors of early biliary complications after liver transplantation were studied.•The time to bile outflow after liver transplantation was evaluated first.•Warm ischemia time and operative time were independent risk factors. The aim of this study was to evaluate the risk factors of early biliary complications (EBC) after liver transplantation (LT) and seek effective treatments based on our single-center experience. A total of 124 adult patients were divided into a non-EBC group and EBC group. EBC usually accounts for biliary leakage, biliary stricture, biliary stones, sphincter of Oddi dysfunction, and transient jaundice within 3 months after LT. Statistical analysis including logistic regression was performed to determine EBC risk factors. All procedures complied with the Helsinki Congress and the Declaration of Istanbul. Non-EBC (n = 95) and EBC (n = 29) were finally compared, which had no difference in their general characteristics. EBC occurred in 29 patients (26.92%): 1 biliary hemorrhage (3.45%), 7 biliary leakage (24.13%), and 16 biliary stricture (55.18%), and 5 others (17.24%). Of all EBC patients, endoscopic retrograde cholangiopancreatography (68.96%) was higher used to deal with complications than conservative treatment (10.35%), percutaneous transhepatic cholangial drainage (17.24%), and surgical treatment (3.45%). On univariate analyses, risk factors for EBC were bilirubin (P = .014), warm ischemia time (WIT) (P = .020), second WIT (P = .042), and operative time (OT) (P = .033). On multivariate analysis, independent risk factors for BC were WIT (P = .011) and OT (P = .049). The presence of WIT and OT were the independent risk factors for the development of EBC. In addition, we also confirmed that endoscopic retrograde cholangiopancreatography was beneficial and safe in the management of EBC after LT.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2022.12.007