Effect of different doses of epidural dexmedetomidine on reducing visceral traction reaction for cesarean section: a double-blind randomized controlled trial

Purpose This study aimed to evaluate the effect of different doses of epidural dexmedetomidine on reducing visceral traction reaction for cesarean section under epidural anesthesia. Methods Nulliparas were randomly allocated to receive epidural ropivacaine alone (group R) or in combination with dexm...

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Bibliographic Details
Published in:Journal of anesthesia 2023-06, Vol.37 (3), p.371-378
Main Authors: Liu, Minghao, Wang, Bin, Prudence, Bizimana, Chen, Xuezi
Format: Article
Language:English
Subjects:
Anesthesia
Anesthesiology
Anesthetics, Local
Cesarean Section
Clinical trials
Critical Care Medicine
Dexmedetomidine
Double-Blind Method
Emergency Medicine
Female
Humans
Infant, Newborn
Intensive
Medicine
Medicine & Public Health
Nausea
Original Article
Pain Medicine
Pregnancy
Ropivacaine
Sufentanil
Traction
Vomiting - chemically induced
Vomiting - prevention & control
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Summary:Purpose This study aimed to evaluate the effect of different doses of epidural dexmedetomidine on reducing visceral traction reaction for cesarean section under epidural anesthesia. Methods Nulliparas were randomly allocated to receive epidural ropivacaine alone (group R) or in combination with dexmedetomidine 0.5 μg/kg (group RD0.5), 0.75 μg/kg (group RD0.75), and 1 μg/kg (group RD1) with 46 nulliparas in each group. The primary outcome was intraoperative visceral traction reaction (graded from 0 to 3, with 0 and 3, respectively, regarded as ‘no discomfort in stomach or perineum; no nausea, vomiting or intestinal tympanites’ and ‘serious visceral pain, nausea and vomiting, intestinal tympanites’). Results Visceral traction reaction was significantly alleviated in group RD0.5, RD0.75, and RD1, respectively, compared to group R while it was comparable among RD groups. Increased Ramsay Sedation Scale and lower incidence of shivering were found in RD groups compared to group R ( p  
ISSN:0913-8668
1438-8359
DOI:10.1007/s00540-023-03166-8