Gene Edited Tumor Cells Kill and Prevent Cancer in Mice

Live cancer cells genetically altered to both attack cancer tumors and stimulate immunity eliminated established glioblastoma tumors and prevented recurrence in mice, according to a report in Science Translational Medicine. The results suggest that cell-based immunotherapies for treating solid tumor...

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Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 2023-02, Vol.329 (5), p.363-363
Main Author: Larkin, Howard D
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Cancer
Cell death
CRISPR-Cas Systems
Gene Editing - methods
Genome editing
Glioblastoma
Immunotherapy
Lymphocytes
Lymphocytes T
Mice
Neoplasms - genetics
Neoplasms - pathology
Neoplasms - prevention & control
Neoplasms - therapy
Solid tumors
Tumor cells
Tumors
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Summary:Live cancer cells genetically altered to both attack cancer tumors and stimulate immunity eliminated established glioblastoma tumors and prevented recurrence in mice, according to a report in Science Translational Medicine. The results suggest that cell-based immunotherapies for treating solid tumors in humans may be possible, according to the authors. The modified tumor cells actively seek out unmodified tumor cells in the body. There, the engineered cells secrete a programmed death factor that directly kills active tumor cells as well as factors that stimulate T cells to attack the tumor.
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.2022.24492