Emerging heterologous mRNA-based booster strategies within the COVID-19 vaccine landscape

Messenger RNA (mRNA)-based vaccine platforms used for the development of mRNA-1273 and BNT162b2 have provided a robust adaptable approach to offer protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, as variants of concern (VoCs), such as omicron and associated s...

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Bibliographic Details
Published in:Human vaccines & immunotherapeutics 2023-12, Vol.19 (1), p.2153532-2153532
Main Authors: Das, Rituparna, Hyer, Randall N., Burton, Paul, Miller, Jacqueline M., Kuter, Barbara J.
Format: Article
Language:English
Subjects:
Antibodies, Neutralizing
Antibodies, Viral
BNT162 Vaccine
Coronavirus – Review
COVID-19
COVID-19 - prevention & control
COVID-19 Vaccines
heterologous booster
Humans
mRNA-1273 vaccine
Review
RNA, Messenger
SARS-CoV-2
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Summary:Messenger RNA (mRNA)-based vaccine platforms used for the development of mRNA-1273 and BNT162b2 have provided a robust adaptable approach to offer protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, as variants of concern (VoCs), such as omicron and associated sub-variants, emerge, boosting strategies must also adapt to keep pace with the changing landscape. Heterologous vaccination regimens involving the administration of booster vaccines different than the primary vaccination series offer a practical, effective, and safe approach to continue to reduce the global burden of coronavirus disease 2019 (COVID-19). To understand the immunogenicity, effectiveness, and safety of heterologous mRNA-based vaccination strategies, relevant clinical and real-world observational studies were identified and summarized. Overall, heterologous boosting strategies with mRNA-based vaccines that are currently available and those in development will play an important global role in protecting individuals from COVID-19 caused by emerging VoCs.
ISSN:2164-5515
2164-554X
DOI:10.1080/21645515.2022.2153532