Diabetes influences the fusion of autophagosomes with lysosomes in SH-SY5Y cells and induces Aβ deposition and cognitive dysfunction in STZ-induced diabetic rats

Diabetes has been regarded as an independent risk factor for Alzheimer’s disease (AD). Our previous study found that diabetes activated autophagy, but lysosome function was impaired. Autophagy-lysosome dysfunction may be involved in Aβ deposition in diabetic cognitive impairment. In the present stud...

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Published in:Behavioural brain research 2023-03, Vol.442, p.114286-114286, Article 114286
Main Authors: Ma, Lou-Yan, Liu, Song-fang, Guo, Ya-gang, Ma, Zheng-quan, Li, Ya, Wang, Shu-jin, Niu, Yu, Li, Mo, Zhai, Jia-jia, Shang, Su-hang, Lv, Ya-Li, Qu, Qiu-Min
Format: Article
Language:English
Subjects:
Animals
Autophagosomes - metabolism
Autophagy
Autophagy flux
Diabetes
Diabetes Mellitus, Experimental - complications
Diabetes Mellitus, Experimental - metabolism
Fusion
Glucose - metabolism
Humans
Lysosome
Lysosomes - metabolism
Neuroblastoma - metabolism
Rats
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Summary:Diabetes has been regarded as an independent risk factor for Alzheimer’s disease (AD). Our previous study found that diabetes activated autophagy, but lysosome function was impaired. Autophagy-lysosome dysfunction may be involved in Aβ deposition in diabetic cognitive impairment. In the present study, we used STZ-induced diabetic rats and SH-SY5Y cells to investigate whether diabetes inhibits autophagosome fusion with lysosomes. We found that in the in vivo study, STZ-induced diabetic rats exhibited cognitive dysfunction, and the lysosome function-related factors CTSL, CTSD, and Rab7 were decreased (P 
ISSN:0166-4328
1872-7549
DOI:10.1016/j.bbr.2023.114286