(Multivariate)-Metal–Organic Framework for Highly Efficient Antibiotic Capture from Aquatic Environmental Matrices

Contamination of aquatic environments by pharmaceuticals used by modern societies has become a serious threat to human beings. Among them, antibiotics are of particular concern due to the risk of creating drug-resistant bacteria and, thus, developing efficient protocols for the capture of this parti...

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Published in:ACS applied materials & interfaces 2023-01, Vol.15 (2), p.3069-3076
Main Authors: Negro, Cristina, Martínez Pérez-Cejuela, Héctor, Simó-Alfonso, Ernesto Francisco, Iqbal, Waseem, Herrero-Martínez, José Manuel, Armentano, Donatella, Ferrando-Soria, Jesús, Pardo, Emilio
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Cephalosporins
Energy, Environmental, and Catalysis Applications
Humans
Metal-Organic Frameworks - chemistry
Penicillins - analysis
Solid Phase Extraction
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Summary:Contamination of aquatic environments by pharmaceuticals used by modern societies has become a serious threat to human beings. Among them, antibiotics are of particular concern due to the risk of creating drug-resistant bacteria and, thus, developing efficient protocols for the capture of this particular type of drug is mandatory. Herein, we report a family of three isoreticular MOFs, derived from natural amino acids, that exhibit high efficiency in the removal of a mixture of four distinct families of antibiotics, such as fluoroquinolones, penicillins, lincomycins, and cephalosporins, as solid-phase extraction (SPE) sorbents. In particular, a multivariate (MTV)-MOF, prepared using equal percentages of amino acids l-serine and l-methionine, also exhibits outstanding recyclability, surpassing the benchmark material activated carbon. The good removal performance of the MTV-MOF was rationalized by means of single-crystal X-ray diffraction. These results highlight the situation of MOFs as a real and promising alternative for the capture of antibiotics from environmental matrices, especially wastewater streams.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.2c20458