Stromal vascular fraction with platelet‐rich plasma injection during surgery is feasible and safe in treatment‐refractory perianal fistulising Crohn's disease: A pilot study

Summary Background An unmet need remains for improved management in perianal fistulising Crohn's disease (pCD). Recently, local administration of adipose‐derived cells has shown promising results. Aims To assess the safety and feasibility of injection of stromal vascular fraction (SVF) with pla...

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Published in:Alimentary pharmacology & therapeutics 2023-04, Vol.57 (7), p.783-791
Main Authors: Arkenbosch, Jeanine H. C., Ruler, Oddeke, Dwarkasing, Roy S., Fuhler, Gwenny M., Schouten, W. Rudolph, Oud‐Alblas, Marjolein Blussé, Graaf, Eelco J. R., Vries, Annemarie C., Woude, C. Janneke
Format: Article
Language:English
Subjects:
Crohn Disease - complications
Crohn Disease - surgery
Crohn's disease
Crohns disease
Curettage
Female
Fistula
Fistulae
Humans
Injection
Magnetic resonance imaging
Male
Patients
perianal fistula
Pilot Projects
Platelet-Rich Plasma
Platelets
platelet‐rich plasma
Rectal Fistula - diagnostic imaging
Rectal Fistula - etiology
Rectal Fistula - surgery
Stromal Vascular Fraction
Surgery
Treatment Outcome
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Summary:Summary Background An unmet need remains for improved management in perianal fistulising Crohn's disease (pCD). Recently, local administration of adipose‐derived cells has shown promising results. Aims To assess the safety and feasibility of injection of stromal vascular fraction (SVF) with platelet‐rich plasma (PRP) in patients with pCD. Methods Patients ≥ 18 years with pCD were included and underwent fistula curettage, SVF with PRP injection, and closure of the internal opening. The primary endpoint was safety at 12 months. The secondary outcomes were complete radiological healing at 3 months (absence of fluid‐containing tracts on MRI) and partial and complete clinical response at 3 and 12 months (closure of ≥1, respectively, all treated external opening(s)). Results Twenty‐five patients were included (35 [IQR 25–40] years; 14 [56%] female); median CD duration 4 [IQR 2–8] years. Twenty‐four (95%) patients had previously undergone fistula surgery. No adverse events were encountered at lipoharvesting sites. Two (8%) patients were readmitted to hospital and six (24%) underwent unplanned re‐interventions. Post‐operative MRI (n = 24) showed complete radiological healing in nine (37.5%) patients. Partial clinical response was present in 48% (12/25) at 3 months and in 68% (17/25) at 12 months, and complete clinical closure in five (20%) patients at 3 months and in 10 (40%) patients at 12 months. Conclusion Injection with autologous SVF with PRP is feasible and safe in patients with treatment‐refractory pCD. Early complete radiological healing was observed in more than one‐third of patients, and clinical response in two‐thirds of patients at 12 months. Stromal vascular fraction with platelet‐rich plasma injection during surgery is feasible and safe in treatment‐refractory perianal fistulising Crohn's disease.
ISSN:0269-2813
1365-2036
DOI:10.1111/apt.17347