Relationships of orexigenic and anorexigenic hormones with body fat distribution in patients with obstructive sleep apnea syndrome

Purpose We aimed to examine the relationships of disease activity and risk factors with serum levels of orexigenic and anorexigenic hormones in patients with obstructive sleep apnea syndrome (OSAS). Methods Fasting blood samples were taken for hormonal analysis of all participants, abdominal/neck bi...

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Bibliographic Details
Published in:European archives of oto-rhino-laryngology 2023-05, Vol.280 (5), p.2445-2452
Main Authors: Or Koca, Arzu, İriz, Ayşe, Hazır, Burak, Şemsi, Rabia, Bilger, Nirgül, Uğraş Dikmen, Asiye, Sepici Dinçel, Aylin, Yetkin, İlhan
Format: Article
Language:English
Subjects:
Body Fat Distribution
Head and Neck
Head and Neck Surgery
Hormones
Humans
Medicine
Medicine & Public Health
Neurosurgery
Otorhinolaryngology
Patient Acuity
Risk Factors
Sleep Apnea, Obstructive
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Summary:Purpose We aimed to examine the relationships of disease activity and risk factors with serum levels of orexigenic and anorexigenic hormones in patients with obstructive sleep apnea syndrome (OSAS). Methods Fasting blood samples were taken for hormonal analysis of all participants, abdominal/neck bioimpedance measurements were recorded, and polysomnography (PSG) analyses were performed. According to the apnea–hypopnea index (AHI), 34 patients with newly diagnosed OSAS and 34 participants without OSAS were compared. Results The median body mass index (BMI) measured in the OSAS group was 30.39 kg/m 2 and AHI was 18.95 and these values were 25.40 kg/m 2 and 1.55 in the control group. There was a higher level of visceral adiposity and neuropeptide Y (NPY) in the moderate-to-severe OSAS group compared to the mild OSAS and control groups, and in the mild OSAS group compared to the control group ( p  = 0.001, p  
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-022-07799-5