Chemical Composition Determination and Evaluation of the Antimicrobial Activity of Essential Oil from Croton blanchetianus (Euphorbiaceae) against Clinically Relevant Bacteria

In this study, the chemical composition of the essential oil (EO) extracted from Croton blanchetianus Baill leaves was identified, and antimicrobial and antibiofilm activities against Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli strains were determined. Moreover, the effec...

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Published in:Chemistry & biodiversity 2023-01, Vol.20 (1), p.e202200777-n/a
Main Authors: Nunes, Aluska Kelly A., Araújo Malveira, Ellen, Lopes Andrade, Alexandre, Barbosa da Silva, Wildson Max, Morais, Selene Maia, Silva dos Santos, Hélcio, Cavalcanti de Albuquerque, Cynthia, Holanda Teixeira, Edson, Nascimento Souza, Diego Nathan, Alves de Vasconcelos, Mayron
Format: Article
Language:English
Subjects:
Ampicillin
Ampicillin - pharmacology
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Antiinfectives and antibacterials
Antimicrobial activity
Antimicrobial agents
Biofilms
Chemical composition
Croton
Croton blanchetianus
E coli
Essential oils
Euphorbiaceae
infections
Microbial Sensitivity Tests
Natural products
Oils, Volatile - chemistry
Oils, Volatile - pharmacology
Sesquiterpenes
Staphylococcus aureus
Strains (organisms)
Synergistic effect
Tetracyclines - pharmacology
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Summary:In this study, the chemical composition of the essential oil (EO) extracted from Croton blanchetianus Baill leaves was identified, and antimicrobial and antibiofilm activities against Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli strains were determined. Moreover, the effects of EO in combination with ampicillin and tetracycline were investigated. Thirty‐four components, mainly mono‐and sesquiterpenes that represented 94.05 % of the chemical composition, were identified in the EO. The EO showed bacteriostatic and bactericidal activities against all strains tested. Furthermore, the EO showed a synergistic effect with ampicillin and tetracycline. EO significantly inhibited biofilm formation and reduced the number of viable cells in biofilms. The EO may be a promising natural product for preventing bacterial biofilm infections.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202200777