Effect of intravesical tarantula cubensis extract (Theranekron) on inflammation in an interstitial cystitis rat model

Objectives To reveal the histopathological and immunological outcomes of intravesical treatment with tarantula cubensis extract (TCE) in a rat model of interstitial cystitis. Methods A total of 30 female Wistar albino rats were divided into three groups: group 1 (control group), group 2 (disease gro...

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Bibliographic Details
Published in:Lower urinary tract symptoms 2023-03, Vol.15 (2), p.63-67
Main Authors: Abdullah, Akdağ, Çiğdem, Yenisey, Tuğrul, Epikmen E., Erhan, Ateş
Format: Article
Language:English
Subjects:
Animals
bladder
Cystitis - pathology
Cystitis, Interstitial - pathology
Disease Models, Animal
Edema
Female
Fibroblasts
Hydroxyproline
Inflammation
Interleukin-6
interstitial cystitis
Necrosis
Rats
Rats, Wistar
tarantula venoms
Tumor Necrosis Factor-alpha
Tumor necrosis factor-TNF
Ulcer
Ulcers
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Summary:Objectives To reveal the histopathological and immunological outcomes of intravesical treatment with tarantula cubensis extract (TCE) in a rat model of interstitial cystitis. Methods A total of 30 female Wistar albino rats were divided into three groups: group 1 (control group), group 2 (disease group), and group 3 (treatment group). The rat model of interstitial cystitis was created by biweekly intraperitoneal administration of cyclophosphamide (CYP). In group 3, TCE (a venom extracted from a brown spider known as tarantula cubensis) was administered intravesically after the model had been created. Urothelial degeneration, necrosis, ulcer, bleeding, edema, inflammation and mast cell count, interleukin‐6 (IL‐6), tumor necrosis factor‐alpha (TNF‐alpha), myeloperoxidase (MPO), and hydroxyproline parameters were evaluated. Statistical analysis was performed using one‐way analysis of variance, chi‐square tests, and Kruskal–Wallis tests. Results All parameters were found to be lower in the rats in group 1 than in the other groups, and IL‐6 and MPO values were found to be higher in group 2 (p 
ISSN:1757-5664
1757-5672
DOI:10.1111/luts.12470