PROspective Meta‐analysis Of Trials of Initial Oxygen in preterm Newborns (PROMOTION): Protocol for a systematic review and prospective meta‐analysis with individual participant data on initial oxygen concentration for resuscitation of preterm infants

Background Clinicians favour low oxygen concentrations when resuscitating preterm infants immediately after birth despite inconclusive evidence to support this practice. Prospective meta‐analysis (PMA) is a novel approach where studies are identified as eligible for inclusion in the meta‐analysis be...

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Bibliographic Details
Published in:Acta Paediatrica 2023-03, Vol.112 (3), p.372-382
Main Authors: Sotiropoulos, James X., Schmölzer, Georg M., Oei, Ju Lee, Libesman, Sol, Hunter, Kylie E., Williams, Jonathan G., Webster, Angela C., Tarnow‐Mordi, William O., Vento, Maximo, Asztalos, Elizabeth, Shah, Prakesh S., Katheria, Anup, Seidler, Anna Lene
Format: Article
Language:English
Subjects:
Female
Gestation
Gestational Age
Humans
individual participant data meta‐analysis
Infant
Infant, Newborn
Infant, Premature
Infants
Meta-analysis
Meta-Analysis as Topic
neonatal resuscitation
Neonates
Newborn babies
Oxygen
oxygen concentration
Premature babies
preterm birth
prospective meta‐analysis
Prospective Studies
Resuscitation - methods
Systematic review
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Summary:Background Clinicians favour low oxygen concentrations when resuscitating preterm infants immediately after birth despite inconclusive evidence to support this practice. Prospective meta‐analysis (PMA) is a novel approach where studies are identified as eligible for inclusion in the meta‐analysis before their results are known. Aims To explore whether high (60%) or low (30%) oxygen is associated with greater efficacy and safety for the initial resuscitation (immediately after birth) of preterm infants born at
ISSN:0803-5253
1651-2227
DOI:10.1111/apa.16622