Long‐term passages of human clonal mesenchymal stromal cells can alleviate the disease in the rat model of collagen‐induced arthritis resembling early passages of different heterogeneous cells

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease of unknown cause. The interaction of immune system cells and the secretion of inflammatory cytokines with synovial cells leads to severe inflammation in the affected joints. Currently, medications, including non‐steroidal anti‐inflam...

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Bibliographic Details
Published in:Journal of tissue engineering and regenerative medicine 2022-12, Vol.16 (12), p.1261-1275
Main Authors: Babaahmadi, Mahnaz, Tayebi, Behnoosh, Gholipour, Nima Makvand, Bendele, Phillip, Pheneger, Jed, Kheimeh, Abolfazl, Kamali, Amir, Molazem, Mohammad, Baharvand, Hossein, Eslaminejad, Mohamadreza Baghaban, Hajizadeh‐Saffar, Ensiyeh, Hassani, Seyedeh‐Nafiseh
Format: Article
Language:English
Subjects:
Animal models
Animals
Arthritis
Arthritis, Experimental - therapy
Arthritis, Rheumatoid - therapy
Autoimmune diseases
Body weight
Bone marrow
Clinical trials
clonal MSCs
Collagen
Collagen (type II)
Cytokines
Drugs
Glucocorticoids
Growth factors
Humans
IgG antibody
Immune system
Immunoglobulin G
Immunosuppressive agents
Inflammation
Interleukin 6
Interleukins
Joint diseases
Mesenchymal Stem Cells
mesenchymal stromal cells
Mesenchyme
Rats
Regenerative medicine
Rheumatoid arthritis
Signs and symptoms
Stromal cells
Tissue engineering
Wharton Jelly
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Summary:Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease of unknown cause. The interaction of immune system cells and the secretion of inflammatory cytokines with synovial cells leads to severe inflammation in the affected joints. Currently, medications, including non‐steroidal anti‐inflammatory drugs, glucocorticoids, and more recently, disease‐modifying anti‐rheumatic drugs, are used to reduce inflammation. However, long‐term use of these drugs causes adverse effects or resistance in a considerable number of RA patients. Recent findings revealed the safety and efficacy of mesenchymal stromal cells (MSCs)‐based therapies both in RA animal models and clinical trials. Here, the beneficial effects of bone marrow‐derived heterogeneous MSCs (BM‐hMSCs) and Wharton jelly‐derived MSCs (WJ‐MSCs) at early passages were compared to BM‐derived clonal MSCs (BM‐cMSCs) at high passage number on a rat model of collagen‐induced arthritis. Results showed that systemic delivery of MSCs significantly reversed adverse changes in body weight, paw swelling, and arthritis score in all MSC‐treated groups. Radiological images and histological evaluation demonstrated the therapeutic effects of MSCs. There was a decrease in serum level of anti‐collagen type II immunoglobulin G and the inflammatory cytokines interleukin (IL)‐1β, IL‐6, IL‐17, and tumor necrosis factor‐α in all MSC‐treated groups. In contrast, an increase in inhibitory cytokines transforming growth factor‐β and IL‐10 was seen. Notably, the long‐term passages of BM‐cMSCs could alleviate RA symptoms similar to the early passages of WJ‐MSCs and BM‐hMSCs. The importance of BM‐cMSCs is the potential to establish cell banks with billions of cells derived from a single donor that could be a competitive cell‐based therapy to treat RA.
ISSN:1932-6254
1932-7005
DOI:10.1002/term.3368