A series of heterogeneous lymphoproliferative diseases with CD3 and MUM1 co-expressed in cats and dogs

Lymphoma diagnosis in dogs and cats is continually evolving as new subtypes and human correlates are being recognized. In humans, T-cell lymphomas with MUM1 expressed and plasma cell neoplasia or B-cell lymphomas with CD3 expressed aberrantly are reported only rarely. We report here a case series of...

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Bibliographic Details
Published in:Journal of veterinary diagnostic investigation 2023-01, Vol.35 (1), p.22-33
Main Authors: Hughes, Kelly L., Rout, Emily D., Avery, Paul R., Pavuk, Alana A., Avery, Anne C., Moore, A Russell
Format: Article
Language:English
Subjects:
Animals
Cat Diseases - diagnosis
Cat Diseases - pathology
Cats
Dog Diseases - diagnosis
Dog Diseases - pathology
Dogs
Humans
Lymphoma - pathology
Lymphoma - veterinary
Lymphoma, B-Cell - pathology
Lymphoma, B-Cell - veterinary
Plasmacytoma - pathology
Plasmacytoma - veterinary
T-Lymphocytes - pathology
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Summary:Lymphoma diagnosis in dogs and cats is continually evolving as new subtypes and human correlates are being recognized. In humans, T-cell lymphomas with MUM1 expressed and plasma cell neoplasia or B-cell lymphomas with CD3 expressed aberrantly are reported only rarely. We report here a case series of tumors in dogs and cats with CD3 and MUM1 co-expressed as determined by immunocytochemistry or immunohistochemistry. Lineage was assigned for these tumors by 3 board-certified pathologists and a veterinary immunologist based on review of clinical and cellular features and the results of ancillary testing including PCR for antigen receptor rearrangements, flow cytometry, and serum protein electrophoresis with immunofixation. In cats, 7 of 7 tumors, and in dogs, 3 of 6 tumors with CD3 and MUM1 co-expressed had clonal rearrangement of the immunoglobulin gene or serum monoclonal immunoglobulin, consistent with a diagnosis of a plasma cell neoplasia or myeloma-related disorder with CD3 expressed aberrantly. Disease was often disseminated; notably, 3 of 7 feline cases had cutaneous and/or subcutaneous involvement in the tarsal area. In dogs, 3 of 6 cases had a clonal T-cell receptor gamma result and no clonal immunoglobulin gene rearrangement and were diagnosed as a T-cell tumor with MUM1 expressed. The use of multiple testing modalities in our series of tumors with plasma-cell and T-cell antigens in dogs and cats aided in the comprehensive identification of the lymphoproliferative disease subtype.
ISSN:1040-6387
1943-4936
DOI:10.1177/10406387221139799