Motivationally salient cue processing measured using the monetary incentive delay (MID) task with electroencephalography (EEG): A potential marker of apathy in Huntington's disease

We explored the utility of the Monetary Incentive Delay (MID) task with concurrent encephalography (EEG) as a marker of apathy in people with Huntington's disease (HD) as well as neurotypical controls. Specifically, we assessed between and within-group differences in the amplitude of the P300 a...

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Bibliographic Details
Published in:Neuropsychologia 2022-12, Vol.177, p.108426-108426, Article 108426
Main Authors: Davis, Marie-Claire, Hill, Aron T., Fitzgerald, Paul B., Stout, Julie C., Hoy, Kate E.
Format: Article
Language:English
Subjects:
Apathy
Contingent negative variation (CNV)
Cues
Electroencephalography
Evoked Potentials
Humans
Huntington Disease
Motivation
P300
Processing speed
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Summary:We explored the utility of the Monetary Incentive Delay (MID) task with concurrent encephalography (EEG) as a marker of apathy in people with Huntington's disease (HD) as well as neurotypical controls. Specifically, we assessed between and within-group differences in the amplitude of the P300 and Contingent Negative Variation (CNV) event-related potentials as a function of motivational salience. In contrast to neurotypical controls, HD participants' ERP amplitudes were not differentially modulated by motivationally salient cues (i.e., signalling potential ‘gain’ or ‘loss’) compared to ‘neutral’ cues. Difference waves isolating amplitude specific to the motivationally salient cues were calculated for the P300 and CNV. Only the difference waves for ERPs elicited by ‘gain’ cues differentiated the groups. The CNV difference wave was also significantly correlated with clinical measures of apathy and processing speed in the HD group. These findings provide initial support for the use of the MID with EEG as a marker of apathy in HD, and its potential as a sensitive outcome measure for novel treatment development. •We explored the EEG version of the Monetary Incentive Delay task in people with HD.•The HD group's ERP amplitudes did not change following motivationally salient cues.•Neurotypical controls' ERPs were enhanced following motivationally salient cues.•Apathy and processing speed correlated with the CNV difference wave in the HD group.•The EEG version of the MID is a potential sensitive marker of apathy in HD.
ISSN:0028-3932
1873-3514
DOI:10.1016/j.neuropsychologia.2022.108426