Selective serotonin reuptake inhibitors as a risk factor for dental implant failure: a retrospective clinical study

The trend in recent decades in Europe and the United States points to an exponential increase in the consumption of antidepressant drugs and, in particular, selective serotonin reuptake inhibitors (SSRIs). This retrospective study aimed to investigate whether there is an association between SSRI int...

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Bibliographic Details
Published in:British journal of oral & maxillofacial surgery 2022-12, Vol.60 (10), p.1347-1352
Main Authors: Rodríguez-Pena, Karen, Salgado-Peralvo, Ángel-Orión, Kewalramani, Naresh, Suárez-Quintanilla, Juan-Antonio, Suárez-Quintanilla, José-María
Format: Article
Language:English
Subjects:
Antidepressant
Dental implant complications
Dental implant failure
Dental implants
Dental Implants - adverse effects
Humans
Retrospective Studies
Risk Factors
Selective serotonin reuptake inhibitors
Selective Serotonin Reuptake Inhibitors - adverse effects
SSRI
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Summary:The trend in recent decades in Europe and the United States points to an exponential increase in the consumption of antidepressant drugs and, in particular, selective serotonin reuptake inhibitors (SSRIs). This retrospective study aimed to investigate whether there is an association between SSRI intake and dental implant (DI) failure or survival and, secondarily, to investigate the influence of other systemic and local factors. This retrospective cohort study was done in accordance with the the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guidelines for observational studies. A total of 170 patients received 573 DIs between 2014 and 2020.The reported DI failure rate was 6.11% (n = 35 DIs). Of these 18.31% failed in patients treated with SSRIs while 4.38% failed in patients who were not prescribed SSRIs (p 
ISSN:0266-4356
1532-1940
DOI:10.1016/j.bjoms.2022.09.009