Epilepsy as a disease affecting neural networks: a neurophysiological perspective

The brain is a series of networks of functionally and anatomically connected, bilaterally represented structures; in epilepsy, activity of any part of the brain affects activity in the other parts. This is relevant for understanding the pathophysiology, diagnosis, and prognosis of the disease. In th...

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Bibliographic Details
Published in:Neurología (Barcelona, English ed. ) English ed. ), 2023-03, Vol.38 (2), p.114-123
Main Authors: San-Juan, D., Rodríguez-Méndez, D.A.
Format: Article
Language:English
Subjects:
Brain - diagnostic imaging
Cirugía de epilepsia
Conectoma
Connectome
EEG
Epilepsia
Epilepsy
Epilepsy - diagnosis
Epilepsy surgery
Humans
Nerve Net
Networks
Neural Networks, Computer
Neuronal
Neurons
Prognosis
Redes
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Summary:The brain is a series of networks of functionally and anatomically connected, bilaterally represented structures; in epilepsy, activity of any part of the brain affects activity in the other parts. This is relevant for understanding the pathophysiology, diagnosis, and prognosis of the disease. In this study, we present a state-of-the-art review of the neurophysiological view of epilepsy as a disease affecting neural networks. We describe the basic and advanced principles of epilepsy as a disease affecting neural networks, based on the use of different clinical and mathematical techniques from a neurophysiological perspective, and signal the limitations of these findings in the clinical context. Epilepsy is a disease affecting complex neural networks. Understanding these will enable better management and prognostic confidence. La epilepsia es un conjunto de redes de estructuras cerebrales representadas bilateralmente, que están funcional y anatómicamente conectadas, en la epilepsia, la actividad de cualquier parte del cerebro afecta la actividad de las demás. Esto es relevante para el entendimiento de la fisiopatología, etiología, el diagnóstico y la prognosis de esta enfermedad. Revisar el estado del arte en cuanto al entendimiento de la visión neurofisiológica de la epilepsia como una enfermedad de redes neuronales. Se describen los principios básicos y avanzados de la epilepsia como enfermedad de redes neuronales usando distintos métodos clínicos y matemáticos con una visión neurofisiológica, indicando las limitaciones de estos hallazgos en el contexto clínico. La epilepsia es una enfermedad de redes neuronales complejas cuyo entendimiento permitirá mejorar los tratamientos disponibles y la certeza pronostica.
ISSN:2173-5808
2173-5808
DOI:10.1016/j.nrleng.2020.06.016