Lignans from the root of Valeriana jatamansi and their biological evaluation

Investigation on the chemical components of Valeriana jatamansi Jones (Caprifoliaceae), a new lignan with pyran-ring, dipsalignan G (1), along with eight known compounds (2-9) were isolated. Their structures were elucidated by extensive analysis of 1D, 2D NMR and HR-ESI-MS spectroscopic data. Additi...

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Bibliographic Details
Published in:Journal of asian natural products research 2023-08, Vol.25 (8), p.810-817
Main Authors: Tan, Yu-Zhu, Wang, Li-Xia, Li, Hong-Xiang, Chen, Hu-Lan, Yan, Yong-Ming, Wang, Yi, Tang, Zhen-Tao, Zhang, Hai, Luo, Qi
Format: Article
Language:English
Subjects:
antioxidant
Biological effects
Caprifoliaceae
Dipsalignan G
Free radicals
lignan
Lignans
NMR
Nuclear magnetic resonance
Scavenging
Two dimensional analysis
Valeriana jatamansi
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Summary:Investigation on the chemical components of Valeriana jatamansi Jones (Caprifoliaceae), a new lignan with pyran-ring, dipsalignan G (1), along with eight known compounds (2-9) were isolated. Their structures were elucidated by extensive analysis of 1D, 2D NMR and HR-ESI-MS spectroscopic data. Additionally, possible biosynthetic pathway of 1 was proposed. Finally, biological evaluation results showed that 8 had significant scavenging ability to ABTS and DPPH free radicals, with IC 50 values of 1.35 ± 0.01 and 2.94 ± 0.01 μg/ml, respectively.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2022.2145958