The Association Between Prebooster Vaccination Antibody Levels and the Risk of Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Abstract The correlation between anti–severe acute respiratory syndrome coronavirus 2 antibody levels and infection was reported. Here, we estimated the role of pre–fourth dose levels using data from 1098 healthcare workers. The risk of infection was reduced by 46% (95% confidence interval, 29%–59%)...

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Bibliographic Details
Published in:Clinical infectious diseases 2023-04, Vol.76 (7), p.1315-1317
Main Authors: Barda, Noam, Canetti, Michal, Gilboa, Mayan, Asraf, Keren, Indenboim, Victoria, Weiss-Ottolenghi, Yael, Amit, Sharon, Zubli, Daniel, Doolman, Ram, Mendelson, Ella, Freedman, Laurence S, Kreiss, Yitshak, Lustig, Yaniv, Regev-Yochay, Gili
Format: Article
Language:English
Subjects:
Antibodies, Viral
COVID-19
Health Personnel
Humans
Immunization, Secondary
Vaccination
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Summary:Abstract The correlation between anti–severe acute respiratory syndrome coronavirus 2 antibody levels and infection was reported. Here, we estimated the role of pre–fourth dose levels using data from 1098 healthcare workers. The risk of infection was reduced by 46% (95% confidence interval, 29%–59%) for each 10-fold increase in prebooster levels. Prebooster antibody levels could be used to optimally time boosters.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciac886