Delayed graft function in pediatric living donor kidney transplantation

Background Pediatric recipients of living donor kidneys have a low rate of delayed graft function (DGF). We examined the incidence, risk factors and outcomes of DGF in pediatric patients who received a living donor allograft. Methods The STARfile was queried to examine all pediatric patients transpl...

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Bibliographic Details
Published in:Pediatric transplantation 2023-03, Vol.27 (2), p.e14432-n/a
Main Authors: Hwang, Christine S., Kadakia, Yash, Sanchez‐Vivaldi, Jorge A., Patel, Madhukar S., Shah, Jigesh A., DeGregorio, Lucia, Desai, Dev M., Vagefi, Parsia A., MacConmara, Malcolm
Format: Article
Language:English
Subjects:
Child
Creatinine
delayed graft function
Delayed Graft Function - epidemiology
Delayed Graft Function - etiology
Dialysis
Graft rejection
Graft Rejection - epidemiology
Graft Survival
Humans
Ischemia
Kidney
Kidney transplantation
Kidney Transplantation - adverse effects
Kidney transplants
living donor
Living Donors
Pediatrics
Risk Factors
Survival
Thrombosis
Tissue Donors
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Summary:Background Pediatric recipients of living donor kidneys have a low rate of delayed graft function (DGF). We examined the incidence, risk factors and outcomes of DGF in pediatric patients who received a living donor allograft. Methods The STARfile was queried to examine all pediatric patients transplanted with a living donor kidney between 2000 and 2020. Donor and recipient demographic data were examined, as were survival and outcomes. Recipients were stratified into DGF and no DGF groups. DGF was defined as the need for dialysis within the first week after transplant. Results 6480 pediatric patients received a living donor (LD) kidney transplant during the study period. 269 (4.2%) developed DGF post‐transplant. Donors were similar in age, creatinine, and cold ischemia time. Recipients of kidneys with DGF were similar in age, sensitization status and HLA mismatch. Focal segmental glomerulosclerosis (FSGS) was the most common diagnosis in recipients with DGF, and allograft thrombosis was the most common cause of graft loss in this group. Small recipients (weight 
ISSN:1397-3142
1399-3046
DOI:10.1111/petr.14432