PGT pregnancies have a similar risk for post-partum complications as naturally conceived pregnancies

Do preimplantation genetic testing (PGT) pregnancies have higher post-partum complications compared with naturally conceived pregnancies? Retrospective cohort study conducted in 2008–2020 at the Shaare Zedek Medical Center (SZMC), including all patients aged 18–45 years old who conceived following P...

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Published in:Reproductive biomedicine online 2023-01, Vol.46 (1), p.189-195
Main Authors: Srebnik, Naama, Sverdlik Kislasi, Yulia, Amosi-Victor, Danielle, Rotshenker-Olshinka, Keren, Eldar-Geva, Talia, Ben-Ami, Ido, Shonberger, Oshrat, Michaeli, Jennia, Grisaru-Granovsky, Sorina, Rotem, Reut
Format: Article
Language:English
Subjects:
Adolescent
Adult
Female
Fertilization in Vitro - adverse effects
Genetic Testing
Humans
IVF
Live Birth
Male
Middle Aged
PGT
Placenta
Post-partum complications
Postpartum Period
Pregnancy
Preimplantation genetic testing
Retrospective Studies
Semen
Third stage of labour
Young Adult
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Summary:Do preimplantation genetic testing (PGT) pregnancies have higher post-partum complications compared with naturally conceived pregnancies? Retrospective cohort study conducted in 2008–2020 at the Shaare Zedek Medical Center (SZMC), including all patients aged 18–45 years old who conceived following PGT with a singleton live birth >24 weeks. Data were collected from computerized hospital databases and patient files. There were two control groups: (i) pregnancies following IVF-ICSI (intracytoplasmic sperm injection); (ii) four neighbourhood controls for each case delivery (two women delivered before and two after) of women with naturally conceived pregnancies. Overall, 120 PGT, 779 IVF-ICSI and 3507 naturally conceived deliveries were included. Demographic variables were similar apart from slightly higher age in the PGT (P = 0.003) and ICSI (P = 0.002) groups (31.07 ± 4.38 PGT, 31.66 ± 5.03 ICSI, 28.77 ± 5.72 naturally conceived). Composite post-partum placental-related complications (manual lysis of placenta, revision of uterine cavity, haemoglobin drop ≥3 g/dl, post-partum haemorrhage, need for blood transfusion) were more prevalent in both the PGT and IVF-ICSI groups as opposed to naturally conceived (20.0% versus 18.9% versus 10.3%, respectively, P 
ISSN:1472-6483
1472-6491
DOI:10.1016/j.rbmo.2022.09.009