Comparison of two titration programmes for adding insulin detemir to oral antidiabetic drugs in patients with poorly controlled type 2 diabetes mellitus

Aim To explore the effect of active insulin titration versus usual titration on glycaemic control in patients with type 2 diabetes mellitus uncontrolled with oral antidiabetic drugs (OADs). Methods In a 24‐week, prospective and randomized study, 172 patients with uncontrolled type 2 diabetes were ra...

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Bibliographic Details
Published in:Diabetes, obesity & metabolism obesity & metabolism, 2023-03, Vol.25 (3), p.700-706
Main Authors: Liu, Sung‐Chen, Chuang, Shih‐Ming, Wang, Chao‐Hung, Chien, Ming‐Nan, Lee, Chun‐Chuan, Chen, Wei‐Che, Leung, Ching‐Hsiang, Lin, Jiun‐Lu
Format: Article
Language:English
Subjects:
Antidiabetics
Blood Glucose
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - drug therapy
Glycated Hemoglobin
Hemoglobin
Humans
Hypoglycemia
Hypoglycemia - complications
Hypoglycemia - prevention & control
Hypoglycemic Agents - administration & dosage
Insulin
Insulin Detemir - administration & dosage
Insulin Glargine - administration & dosage
insulin therapy
Prospective Studies
randomized controlled trial
Titration
type 2 diabetes mellitus
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Summary:Aim To explore the effect of active insulin titration versus usual titration on glycaemic control in patients with type 2 diabetes mellitus uncontrolled with oral antidiabetic drugs (OADs). Methods In a 24‐week, prospective and randomized study, 172 patients with uncontrolled type 2 diabetes were randomly assigned to either active titration or usual titration. Efficacy and safety outcomes included changes in glycated haemoglobin (HbA1c) and fasting plasma glucose, percentage of individuals achieving HbA1c
ISSN:1462-8902
1463-1326
DOI:10.1111/dom.14912