Plasma IGFBP‐1, Fas, kallistatin, and P‐selectin as predictive biomarkers of histologic chorioamnionitis and associated intra‐amniotic infection in women with preterm labor

Problem To determine whether altered levels of 13 plasma biomarkers, alone or in combination, could be independently associated with histologic chorioamnionitis (HCA) and microbial‐associated HCA (defined as the presence of HCA along with microbial invasion) in women with preterm labor (PTL). Method...

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Published in:American journal of reproductive immunology (1989) 2023-01, Vol.89 (1), p.e13645-n/a
Main Authors: Lee, Kyong‐No, Cho, Iseop, Im, Eun Mi, Oh, Eunji, Park, Kyo Hoon
Format: Article
Language:English
Subjects:
Amniocentesis
Amniotic Fluid
biomarker
Biomarkers
Chorioamnionitis
Chorioamnionitis - diagnosis
Enzyme-linked immunosorbent assay
Female
Fetal alcohol syndrome
Gestational age
Haptoglobin
histologic chorioamnionitis
Humans
Infant, Newborn
Matrix Metalloproteinase 2
microbial invasion of the amniotic cavity
multi‐biomarker panel
Obstetric Labor, Premature
Pentraxins
Plasma
Prediction models
Pregnancy
preterm labor
Retrospective Studies
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Summary:Problem To determine whether altered levels of 13 plasma biomarkers, alone or in combination, could be independently associated with histologic chorioamnionitis (HCA) and microbial‐associated HCA (defined as the presence of HCA along with microbial invasion) in women with preterm labor (PTL). Methods of Study This was a retrospective cohort study involving 77 singleton pregnant women with PTL (23–34 gestational weeks) who delivered within 96 h of plasma and amniotic fluid (AF) sampling. DKK‐3, E‐selectin, Fas, haptoglobin, IGFBP‐1, kallistatin, MMP‐2, MMP‐8, pentraxin 3, progranulin, P‐selectin, SAA4, and TGFBI levels were assayed in plasma samples by ELISA. AF obtained via amniocentesis was used for microorganism identification. Results Multiple logistic regression analyses revealed significant associations between low plasma IGFBP‐1 levels and acute HCA, and between low plasma Fas and kallistatin levels, and elevated plasma P‐selectin levels and microbial‐associated HCA (all p 
ISSN:1046-7408
1600-0897
DOI:10.1111/aji.13645