Analysis of Meibomian Glands in Juvenile Systemic Lupus Erythematosus Patients without Dry Eye Symptoms and Signs

Purpose To evaluate meibomian gland loss and its possible association with disease duration and activity in Juvenile Systemic Lupus Erythematosus (JSLE) patients’ without dry eye symptoms or signs. Study design: Prospective clinical study. Methods Ten eyes of 10 JSLE patients were evaluated using th...

Full description

Saved in:
Bibliographic Details
Published in:Japanese journal of ophthalmology 2023-01, Vol.67 (1), p.32-37
Main Authors: Yılmaz Tuğan, Büşra, Sönmez, Hafize Emine, Şahin, Nihal, Yüksel, Nurşen
Format: Article
Language:English
Subjects:
Autoimmune diseases
Child
Chronic conditions
Clinical Investigation
Dry Eye Syndromes - diagnosis
Dry Eye Syndromes - etiology
Evaluation
Eye
Eye examinations
Eyelid Diseases - diagnosis
Eyelid Diseases - etiology
Glands
Humans
Life expectancy
Life span
Lupus
Medicine
Medicine & Public Health
Meibomian Glands - diagnostic imaging
Ophthalmology
Physical Examination
Prospective Studies
Signs and symptoms
Systemic lupus erythematosus
Tears
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose To evaluate meibomian gland loss and its possible association with disease duration and activity in Juvenile Systemic Lupus Erythematosus (JSLE) patients’ without dry eye symptoms or signs. Study design: Prospective clinical study. Methods Ten eyes of 10 JSLE patients were evaluated using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and 14 eyes of 14 healthy controls were also enrolled. Ocular Surface Disease Index (OSDI) questionnaire and Schirmer I test were performed. Lid margin score, meibum quality and expressibility scores were evaluated. Noninvasive first breakup time (NIF-BUT) and noninvasive average breakup time (NIAvg-BUT), meibomian gland dropout area (MGDA) and meibography scores were evaluated using non-contact meibography (Sirius; CSO). Results There was no significant difference between the JSLE patients and the healthy controls in the OSDI, NIF-BUT, NIAvg-BUT and Schirmer I tests. Also lid margin score, meibum quality and expressibility scores were not significantly different between the groups. However, JSLE patients had increased upper and lower lid MGDA and increased upper lid, lower lid and total meibography scores compared to the healthy subjects. Furthermore, the duration of JSLE showed a high positive correlation with upper and lower lid MGDA and meibography scores. Conclusion Meibomian gland loss could be observed in JSLE patients with no clinical signs and symptoms of dry eye. Considering the longer life expectancy of children, the positive correlation of disease duration with the meibomian gland reveals the importance of routine eye examinations from the diagnosis of the disease.
ISSN:0021-5155
1613-2246
DOI:10.1007/s10384-022-00946-9