Lobularity rather than hyperechoic foci/stranding on endoscopic ultrasonography is associated with more severe histological features in chronic pancreatitis

Background and Aim Endoscopic ultrasonography (EUS) findings of the pancreatic parenchyma, such as hyperechoic foci/stranding and lobularity, may be associated with the severity of chronic pancreatitis (CP). However, the correlation between parenchymal EUS findings and histology remains unclear. We...

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Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2023-01, Vol.38 (1), p.103-111
Main Authors: Inomata, Noriko, Masuda, Atsuhiro, Yamakawa, Kohei, Takenaka, Mamoru, Tsujimae, Masahiro, Toyama, Hirochika, Sofue, Keitaro, Sakai, Arata, Kobayashi, Takashi, Tanaka, Takeshi, Yamada, Yasutaka, Ashina, Shigeto, Gonda, Masanori, Abe, Shohei, Masuda, Shigeto, Uemura, Hisahiro, Kohashi, Shinya, Nagao, Kae, Harada, Yoshiyuki, Miki, Mika, Nakano, Ryota, Shiomi, Hideyuki, Kanzawa, Maki, Itoh, Tomoo, Fukumoto, Takumi, Kodama, Yuzo
Format: Article
Language:English
Subjects:
Atrophy
chronic pancreatitis
endoscopic ultrasonography
Endoscopy
Endosonography
Fibrosis
histology
Humans
hyperechoic foci/stranding
Inflammation
lobularity
Pancreas
Pancreatitis
Pancreatitis, Chronic - pathology
Parenchyma
Patients
Retrospective Studies
Tumors
Ultrasonic imaging
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Summary:Background and Aim Endoscopic ultrasonography (EUS) findings of the pancreatic parenchyma, such as hyperechoic foci/stranding and lobularity, may be associated with the severity of chronic pancreatitis (CP). However, the correlation between parenchymal EUS findings and histology remains unclear. We designed a large‐scale retrospective study analyzing over 200 surgical specimens to elucidate the association between parenchymal EUS findings and histological features. Methods Clinical data of 221 patients with pancreatobiliary tumors who underwent preoperative EUS and pancreatic surgery between January 2010 and November 2020 were reviewed to investigate the association between parenchymal EUS findings and histological features at the pancreatic body. None of these patients met the definition of CP. Results Of the 221 patients, 87 (39.4%), 89 (40.2%), and 45 (20.4%) had normal EUS findings, hyperechoic foci/stranding without lobularity, and hyperechoic foci/stranding with lobularity, respectively. In the multivariate analyses, parenchymal EUS findings significantly correlated with histological CP findings of fibrosis, inflammation, and atrophy (hyperechoic foci/stranding without lobularity vs hyperechoic foci/stranding with lobularity, odds ratio [95% confidence interval]: 4.1 [2.2–7.9] vs 31.3 [9.3–105.6], Ptrend 
ISSN:0815-9319
1440-1746
DOI:10.1111/jgh.16047