Sequential hypothermic and normothermic perfusion preservation and transplantation of expanded criteria donor livers

The purpose of this study was to assess the safety and feasibility of sequential hypothermic oxygenated perfusion and normothermic machine perfusion and the potential benefits of graft viability preservation and assessment before liver transplantation. With the Food and Drug Administration and insti...

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Bibliographic Details
Published in:	Surgery 2023-03, Vol.173 (3), p.846-854
Main Authors:	Liu, Qiang, Del Prete, Luca, Ali, Khaled, Grady, Patrick, Bilancini, Mary, Etterling, John, D’Amico, Giuseppe, Diago Uso, Teresa, Hashimoto, Koji, Aucejo, Federico, Fujiki, Masato, Eghtesad, Bijan, Sasaki, Kazunari, Kwon, Choon Hyuck David, Chaudhry, Sulemon, Doi, Junshi, Pita, Alejandro, New, Brandon, Bennett, Ana, Cywinski, Jacek, Miller, Charles, Quintini, Cristiano
Format:	Article
Language:	eng
Subjects:	Brain Death Humans Lactates Liver Transplantation Living Donors Organ Preservation Perfusion
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Summary:	The purpose of this study was to assess the safety and feasibility of sequential hypothermic oxygenated perfusion and normothermic machine perfusion and the potential benefits of graft viability preservation and assessment before liver transplantation. With the Food and Drug Administration and institutional review board approval, 17 expanded criteria donor livers underwent sequential hypothermic oxygenated perfusion and normothermic machine perfusion using our institutionally developed perfusion device. Expanded criteria donor livers were from older donors, donors after cardiac death, with steatosis, hypertransaminasemia, or calcified arteries. Perfusion duration ranged between 1 and 2 hours for the hypothermic oxygenated perfusion phase and between 4 and 9 hours for the normothermic machine perfusion phase. Three livers were judged to be untransplantable during normothermic machine perfusion based on perfusate lactate, bile production, and macro-appearance. One liver was not transplanted because of recipient issue after anesthesia induction and failed reallocation. Thirteen livers were transplanted, including 9 donors after cardiac death livers (donor warm ischemia time 16–25 minutes) and 4 from donors after brain death. All livers had the standardized lactate clearance >60% (perfusate lactate cleared to
ISSN:	0039-6060 1532-7361