Exploring (peri-) lesional and structural connectivity tissue damage through T1/T2-weighted ratio in iron rim multiple sclerosis lesions

In multiple sclerosis (MS), iron rim lesions (IRLs) on magnetic resonance imaging (MRI) are associated with pronounced intralesional tissue damage. The aim of this study was to investigate (peri-)lesional and structural connectivity tissue damage in IRLs compared to non-IRLs. MRI was acquired on a 3...

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Bibliographic Details
Published in:Magnetic resonance imaging 2023-01, Vol.95, p.12-18
Main Authors: Wittayer, Matthias, Weber, Claudia E, Krämer, Julia, Platten, Michael, Schirmer, Lucas, Gass, Achim, Eisele, Philipp
Format: Article
Language:English
Subjects:
Brain - pathology
Humans
Iron
Magnetic Resonance Imaging - methods
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - pathology
White Matter - pathology
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Summary:In multiple sclerosis (MS), iron rim lesions (IRLs) on magnetic resonance imaging (MRI) are associated with pronounced intralesional tissue damage. The aim of this study was to investigate (peri-)lesional and structural connectivity tissue damage in IRLs compared to non-IRLs. MRI was acquired on a 3 T system. Tissue integrity was assessed using the T1/T2-weighted (T1/T2w) ratio. Furthermore, we assessed the impact on structural network connectivity accounting for differences in lesion volumes and T1/T2w values. Seventy-six patients (38 with at least one IRL and 38 age- and sex-matched patients without IRLs) were included. In the IRL-group, T1/T2w ratios of IRLs were significantly lower compared to non-IRLs (p 
ISSN:0730-725X
1873-5894
DOI:10.1016/j.mri.2022.10.009