Evaluation of faecal lactoferrin as a morbidity biomarker in Schistosoma mansoni infection

Objective Lactoferrin is an 80 KDa iron‐binding glycoprotein that plays a significant role in the innate immune system and is considered to be an important microbicide molecule. This study aimed to assess the concentration of lactoferrin in Schistosoma mansoni‐infected cases before and after praziqu...

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Published in:Tropical medicine & international health 2022-12, Vol.27 (12), p.1053-1058
Main Authors: Elhadad, Heba, Mohamed, Mostafa A., Mohamed, Marwa Morsy, Abdo, Sarah
Format: Article
Language:English
Subjects:
Acetic acid
Adolescent
Adult
Animals
Biomarkers
Child
Child, Preschool
Cross-Sectional Studies
diagnosis
Ethyl acetate
Feces
Feces - parasitology
Glycoproteins
Humans
Immune system
Infections
inflammatory marker
Innate immunity
Lactoferrin
Male
Morbidity
Parasites
Parasitic diseases
Praziquantel
Prevalence
Samples
Schistosoma mansoni
schistosomiasis
Schistosomiasis mansoni - epidemiology
Statistical analysis
Young Adult
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Summary:Objective Lactoferrin is an 80 KDa iron‐binding glycoprotein that plays a significant role in the innate immune system and is considered to be an important microbicide molecule. This study aimed to assess the concentration of lactoferrin in Schistosoma mansoni‐infected cases before and after praziquantel treatment. Methods A cross‐sectional study was carried out on 250 individuals aged from 5 to 30 years. Stool samples were examined for the presence of parasitic infections using Kato‐Katz and formalin ethyl acetate techniques. All S. mansoni‐positive cases were treated with praziquantel and stool samples were recollected 21 days later. Faecal lactoferrin level was determined before and after treatment. Results The prevalence of S. mansoni infection was 14.4%. Among 36 participants infected with S. mansoni, the cure rate was 91.7%. A statistically significant difference in the mean lactoferrin level before and after treatment was detected (1648.95 pg/ml ± 656.5 vs. 1162.8 pg/ml ± 356.8). This difference was statistically significant in the middle and older age groups, in males and in the absence of coinfection with other parasites. Conclusion Lactoferrin could be a promising biomarker associated with S. mansoni infection, however, it could not be used to assess the severity of infection.
ISSN:1360-2276
1365-3156
DOI:10.1111/tmi.13826