Inflammatory Phenotype by OCT Coronary Imaging: Specific Features Among De Novo Lesions, In-Stent Neointima, and In-Stent Neo-Atherosclerosis

Coronary stenosis can be caused de novo atherosclerosis, in-stent restenosis, and in-stent neoatherosclerosis, three entities that develop from a diverse pathophysiological milieu. This study aims to investigate, using optical coherence tomography (OCT), whether or not coronary lesions related to th...

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Published in:Arquivos brasileiros de cardiologia 2022-12, Vol.119 (6), p.931-937
Main Authors: Pinheiro, Luiz Fernando M, Garzon, Stefano, Mariani, Jr, José, Prado, Guy F Almeida, Caixeta, Adriano Mendes, Almeida, Breno Oliveira, Lemos, Pedro Alves
Format: Article
Language:eng ; por
Subjects:
Atherosclerosis - complications
Atherosclerosis - diagnostic imaging
Constriction, Pathologic
Coronary Restenosis - diagnostic imaging
Coronary Restenosis - etiology
Coronary Restenosis - pathology
Coronary Vessels - diagnostic imaging
Drug-Eluting Stents
Heart Valve Diseases - pathology
Humans
Neointima - complications
Neointima - diagnostic imaging
Neointima - pathology
Percutaneous Coronary Intervention - adverse effects
Phenotype
Retrospective Studies
Stents - adverse effects
Tomography, Optical Coherence - adverse effects
Tomography, Optical Coherence - methods
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Summary:Coronary stenosis can be caused de novo atherosclerosis, in-stent restenosis, and in-stent neoatherosclerosis, three entities that develop from a diverse pathophysiological milieu. This study aims to investigate, using optical coherence tomography (OCT), whether or not coronary lesions related to these processes differ in their local inflammatory profile. Retrospective analysis of patients with diagnosed or suspected coronary lesions who had undergone OCT imaging for clinical reasons. Macrophage and intra-plaque neovascularization were assessed by OCT and used as surrogates of local inflammation. A significance level of < 0.05 was adopted as statistically significant. From the 121 lesions, 74 were de novo, 29 were restenosis, and 18 were neoatherosclerosis. Neovascularization was found in 65.8% of de novo, 10.3% in restenosis, and 94.4% in neoatherosclerosis (p
ISSN:1678-4170
DOI:10.36660/abc.20220045