Centralized nociplastic pain causing fibromyalgia: an emperor with no cloths?

The leading school of thought views fibromyalgia as a central sensitization syndrome. Nociplastic pain is the recently proposed term to mechanistically explain central sensitization. Accumulating research suggests an alternate explanation; fibromyalgia can be conceptualized as a neuropathic pain syn...

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Bibliographic Details
Published in:Clinical rheumatology 2022-12, Vol.41 (12), p.3915-3917
Main Author: Martínez-Lavín, Manuel
Format: Article
Language:English
Subjects:
Brain research
Central Nervous System Sensitization
Cerebrospinal fluid
Chronic Pain
Denervation
Diabetes
Diabetic neuropathy
Dorsal root ganglia
Fibromyalgia
Fibromyalgia - complications
Ganglia, Spinal
Humans
Magnetic resonance imaging
Medical research
Medicine
Medicine & Public Health
Nervous system
Neuralgia
Neurosciences
Pathogenesis
Perspectives in Rheumatology
Rheumatology
Severe acute respiratory syndrome coronavirus 2
Syndrome
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Summary:The leading school of thought views fibromyalgia as a central sensitization syndrome. Nociplastic pain is the recently proposed term to mechanistically explain central sensitization. Accumulating research suggests an alternate explanation; fibromyalgia can be conceptualized as a neuropathic pain syndrome and dorsal root ganglia (not the brain) as the primary fibromyalgia pain source. There is no need to propose nociplastic pain as new chronic pain mechanism.
ISSN:0770-3198
1434-9949
1434-9949
DOI:10.1007/s10067-022-06407-5