An electrochemiluminescence dual “turn-on” strategy for alkaline phosphatase detection using a dual quenching Ru(bpy)32+ encapsulated zeolite imidazole metal organic framework

An electrochemiluminescence dual “turn-on” strategy is first designed to detect alkaline phosphatase (ALP) using a dual quenching Ru(bpy)32+ encapsulated zeolite imidazole metal organic framework (Ru(bpy)32+@ZIF-90). Resonance energy transfer (ECRET) makes ECL “turn-off”. Ascorbic acid 2-phosphate i...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2022-10, Vol.58 (86), p.12114-12117
Main Authors: Du, Chengpei, Wang, Yi, Kanglin Pei, Wu, Di, Qi, Wenjing
Format: Article
Language:English
Subjects:
Alkaline phosphatase
Ascorbic acid
Electrochemiluminescence
Encapsulation
Energy transfer
Imidazole
Metal-organic frameworks
Quenching
Zeolites
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Summary:An electrochemiluminescence dual “turn-on” strategy is first designed to detect alkaline phosphatase (ALP) using a dual quenching Ru(bpy)32+ encapsulated zeolite imidazole metal organic framework (Ru(bpy)32+@ZIF-90). Resonance energy transfer (ECRET) makes ECL “turn-off”. Ascorbic acid 2-phosphate is hydrolyzed into PO43− and ascorbic acid (AA) by ALP. PO43− decomposes Ru(bpy)32+@ZIF-90 and AA prevents ECRET, which makes ECL “turn-on” again.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc04270c