Survey of intrauterine red blood cell (RBC) transfusion practices in the United States

Background A paucity of data exists about the current practice of fetal red blood cell (RBC) transfusion in the United States (US). This investigation describes intrauterine transfusion (IUT) RBC product selection and processing practices at different US institutions. Methods A transfusion medicine...

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Bibliographic Details
Published in:Transfusion (Philadelphia, Pa.) Pa.), 2022-12, Vol.62 (12), p.2449-2453
Main Authors: Bakhtary, Sara, Panchalee, Tachjaree, Crowe, Elizabeth P., Schwab, Marisa E., Zakieh, Abdulhafiz, Josephson, Cassandra D., Sobhani, Nasim C., Gonzalez‐Velez, Juan M., Goel, Ruchika
Format: Article
Language:English
Subjects:
Alloantibodies
Blood transfusion
Erythrocytes
Family
Fetuses
Hematocrit
Heterogeneity
Humans
Institutions
Irradiation
Leukocytes
Medicine
Radiation
Standardization
Surveys
Transfusion
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Summary:Background A paucity of data exists about the current practice of fetal red blood cell (RBC) transfusion in the United States (US). This investigation describes intrauterine transfusion (IUT) RBC product selection and processing practices at different US institutions. Methods A transfusion medicine and maternal‐fetal medicine (MFM) team designed a survey to interrogate and characterize RBCs utilized for IUT. This survey was distributed to seventy US institutions with fetal treatment centers (October 2020–April 2021) identified through the NAFTNet (North American Fetal Therapy Network). Results Thirty‐seven institutions responded (response rate 53%, 37/70), but five were excluded for not performing IUTs. Most (84%; 27/32) performed 1–24 IUTs annually; two performed >50 IUTs/year. Group O, Rh(D) negative RBC units were always used by 66% (21/32), and 75% (24/32) provided hemoconcentrated RBCs by washing (17/24) or dry packing (6/24). Overall, 66% (21/32) targeted a hematocrit ≥75%. Fifty percent provided both leukocyte‐reduced and CMV‐negative RBC units. Irradiation of RBC units was performed within 6 h of issue at 63% (20/32) of sites. Most (81%, 26/32) used RBC units at
ISSN:0041-1132
1537-2995
DOI:10.1111/trf.17134